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INFECTIOUS MONONUCLEOSIS: CLINICAL AND LABORATORY FEATURES IN CHILDREN OF THE SAMARKAND REGION

Yarmukhamedova Makhbuba Kudratovna1, Iskhakova Kamila22025

  1. 1Associate Professor of the Department of Infectious Diseases, Samarkand State Medical University.
  2. 2Group 216 of Faculty of General Medicine , Samarkand State Medical University.

KonferensiyalarRepublican scientific-practical conference on “New Paradigms in Science, Technology and Education”Jild 1Son 4Sahifa 504–508

Annotatsiya

Yuqumli mononukleoz (IM) - bu asosan Herpesviridae oilasining a‘zosi bo‘lgan Epstein-Barr virusi (EBV) keltirib chiqaradigan klinik jihatdan ahamiyatli virusli infeksiya. Dunyo aholisining taxminan 80-90% hayoti davomida EBV infektsiyasini yuqtiradi. Yuqumli mononukleozni erta va aniq aniqlash, ayniqsa, isitma davomiyligini kamaytirish, limfoid to‘qimalarning ko‘payishini pasaytirish va gepatotsellyulyar sitolizning tezlashishi orqali davolash natijalarini yaxshilashga yordam beradi.

Boshqa tillarda

inglizchaINFECTIOUS MONONUCLEOSIS: CLINICAL AND LABORATORY FEATURES IN CHILDREN OF THE SAMARKAND REGION

Infectious mononucleosis (IM) is a clinically significant viral infection causedpredominantly by the Epstein–Barr virus (EBV), a member of the Herpesviridae family. Approximately80–90% of the global population acquires EBV infection during their lifetime. Early and accurateidentification of infectious mononucleosis contributes to improved treatment outcomes, especially throughreducing the duration of fever, lowering lymphoid tissue proliferation, and accelerating the resolution ofhepatocellular cytolysis.

o‘zbekINFEKTSIONLI MONONUKLEOZ: SAMARQAND VILOYATI BOLALARIDA KLINIK VA LABORATORATOR XUSUSIYATLARI

Yuqumli mononukleoz (IM) - bu asosan Herpesviridae oilasining a‘zosi bo‘lgan Epstein-Barr virusi (EBV) keltirib chiqaradigan klinik jihatdan ahamiyatli virusli infeksiya. Dunyo aholisining taxminan 80-90% hayoti davomida EBV infektsiyasini yuqtiradi. Yuqumli mononukleozni erta va aniq aniqlash, ayniqsa, isitma davomiyligini kamaytirish, limfoid to‘qimalarning ko‘payishini pasaytirish va gepatotsellyulyar sitolizning tezlashishi orqali davolash natijalarini yaxshilashga yordam beradi.

ruschaИНФЕКЦИОННЫЙ МОНОНУКЛЕЗ: КЛИНИЧЕСКИЕ И ЛАБОРАТОРНЫЕ ОСОБЕННОСТИ У ДЕТЕЙ САМАРКАНДСКОЙ ОБЛАСТИ

Инфекционный мононуклеоз (ИМ) — это клинически значимая вирусная инфекция, вызываемаяпреимущественно вирусом Эпштейна-Барр (ВЭБ), представителем семейства Herpesviridae. Приблизительно80–90% населения мира заражается ВЭБ в течение жизни. Ранняя и точнаядиагностика инфекционного мононуклеоза способствует улучшению результатов лечения, особенно за счетсокращения продолжительности лихорадки, снижения пролиферации лимфоидной ткани и ускорения разрешениягепатоцеллюлярного цитолиза.

Kalit so‘zlar

  • infectious mononucleosis
  • Epstein–Barr virus (EBV)
  • atypical mononuclear cells
  • children
  • clinical features

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INFECTIOUS MONONUCLEOSIS: CLINICAL AND LABORATORY FEATURES IN CHILDREN OF THE SAMARKAND REGION

Yarmukhamedova Makhbuba Kudratovna Associate Professor of the Department of Infectious Diseases, Samarkand State Medical University. Iskhakova Kamila Group 216 of Faculty of General Medicine , Samarkand State Medical University.

Annotation. Infectious mononucleosis (IM) is a clinically significant viral infection caused predominantly by the Epstein–Barr virus (EBV), a member of the Herpesviridae family. Approximately 80–90% of the global population acquires EBV infection during their lifetime. Early and accurate identification of infectious mononucleosis contributes to improved treatment outcomes, especially through reducing the duration of fever, lowering lymphoid tissue proliferation, and accelerating the resolution of hepatocellular cytolysis. Key words: infectious mononucleosis, Epstein–Barr virus (EBV), atypical mononuclear cells, children, clinical features

SAMARQAND VILOYATI BOLALARIDA INFEKSION MONONUKLYOZNING KLINIK VA LABORATOR XUSUSIYATLARI

Annotatsiya. Infeksion mononuklyoz (IM) – asosan Herpesviridae oilasiga mansub Epstein–Barr virusi (EBV) tomonidan chaqiriladigan klinik jihatdan muhim virusli infeksiyadir. Aholining taxminan 80– 90% umri davomida EBV infeksiyasini yuqtiradi. Infeksion mononuklyozni erta va aniq aniqlash davolash natijalarini yaxshilaydi, xususan, isitma davomiyligini kamaytiradi, limfoid to‘qimalarning ko‘payishini pasaytiradi va gepatotsellulyar sitolizning tezroq qaytishiga yordam beradi. Kalit so‘zlar: infeksion mononuklyoz, Epstein–Barr virusi (EBV), atipik mononuklear hujayralar, bolalar, klinik belgilari.

КЛИНИЧЕСКИЕ И ЛАБОРАТОРНЫЕ ОСОБЕННОСТИ ИНФЕКЦИОННОГО МОНОНУКЛЕОЗА У ДЕТЕЙ САМАРКАНДСКОЙ ОБЛАСТИ

Аннотация. Инфекционный мононуклеоз (ИМ) — клинически значимая вирусная инфекция, вызываемая преимущественно вирусом Эпштейна–Барр (ВЭБ), относящимся к семейству Herpesviridae. Около 80–90% населения мира инфицируется ВЭБ в течение жизни. Ранняя и точная диагностика инфекционного мононуклеоза способствует улучшению результатов лечения,

в частности сокращает продолжительность лихорадки, уменьшает пролиферацию лимфоидной ткани и ускоряет разрешение гепатоцеллюлярного цитолиза. Ключевые слова: инфекционный мононуклеоз, вирус Эпштейна–Барр (ВЭБ), атипичные мононуклеарные клетки, дети, клинические проявления.

Introduction Infectious diseases continue to be a dominant component of global morbidity. WHO projections indicate that in the 21st century, viral infections will play an increasingly significant role in overall disease burden. Among viral pathogens, herpesviruses represent a particularly relevant group due to their lifelong persistence in the human body. Epstein–Barr virus, one of the most studied herpesviruses, is responsible for infectious mononucleosis — a disease frequently observed in children and adolescents. EBV infection is notable for: • its high rate of global prevalence, • ability to establish lifelong latency in B lymphocytes, • potential to trigger immune dysregulation and contribute to secondary immunodeficiency. Despite spontaneous recovery in most cases, EBV infection may lead to long-term consequences, including chronic fatigue syndrome, autoimmune disorders, and in rare cases, oncological complications (e.g., Burkitt lymphoma, nasopharyngeal carcinoma), particularly in genetically predisposed individuals. Considering the increasing incidence of EBV-associated diseases worldwide, studying infectious mononucleosis in regional pediatric populations is clinically important. Purpose of the Study To investigate the clinical manifestations, epidemiological characteristics, and laboratory indicators of infectious mononucleosis caused by Epstein–Barr virus in children hospitalized in the Samarkand region. Materials and Methods The study included 21 children aged 3–10 years treated at a regional infectious disease hospital. Inclusion criteria: • typical clinical symptoms of infectious mononucleosis, • laboratory confirmation of EBV infection. Diagnostic procedures performed: Diagnostic category Methods used Clinical evaluation ENT examination, evaluation of lymph node involvement, abdominal palpation

General laboratory CBC, urinalysis, stool examination tests

Specific diagnostics PCR for EBV DNA in serum, detection of atypical mononuclear cells

Patients were classified by age, sex, severity of disease, and organ involvement (lymph nodes, liver, spleen). Disease severity was graded according to standard pediatric infectious disease guidelines. Results and Discussion Most children (57.1%) were between 3–7 years old, demonstrating the predominance of EBV infection in preschool-aged patients. Boys constituted 66.7% of cases. A significant proportion of children initially received treatment from ENT specialists for incorrectly diagnosed tonsillitis, which delayed correct diagnosis and led to hospitalization in the second week of illness. Symptoms observed: Clinical manifestation % of children

Sore throat 90.5% Nasal obstruction 85.7% Headache 85.7% Malaise and weakness 76.2% Cough 28.6% Excessive sweating 71.4% Hyperthermia was recorded in all children prior to hospitalization. Fever lasted 8–11 days and showed an irregular pattern. Pharyngeal examination revealed otorhinolaryngologic forms of tonsillitis: • Catarrhal — 52.4% • Follicular — 28.6% • Lacunar — 19% Lymphadenopathy was bilateral in all cases. Lymph nodes ranged from pea-sized to walnut-sized and remained mobile and non-adherent—signs consistent with benign reactive lymphoid hyperplasia. Due to delayed hospitalization, organ enlargement was frequently observed: Organ change % of children

CBC revealed leukocytosis in most children, reaching up to 25.0 ×10⁹/L in severe cases. Mild anemia was detected in 85.7% of patients. Atypical mononuclear cells — the key diagnostic marker of infectious mononucleosis — were present in 76.2% of children. Biochemical liver abnormalities correlated with hepatomegaly: elevated AST and ALT levels were documented, although bilirubin and thymol tests remained normal, indicating moderate cytolytic syndrome without cholestasis. Conclusion The study demonstrates that: • Infectious mononucleosis in children of the Samarkand region occurs predominantly in a moderate clinical form. • Most patients present late (on days 7–14), which increases the risk of hepatosplenomegaly. • Atypical mononuclear cells and PCR confirmation of EBV remain the most reliable diagnostic indicators. Early recognition and differential diagnosis — particularly distinguishing IM from common tonsillitis — are essential for preventing complications and reducing unnecessary antibiotic use.

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Metama’lumot

Identifikator
REL-C-011403
Nashr sanasi
2025-12-05
Til
inglizcha
Konferensiyalar
Republican scientific-practical conference on “New Paradigms in Science, Technology and Education”
Jild
1
Son
4
DOI
10.66073/refocus-conf/411
Nashriyot
LLC Ilm-fan va innovatsiyalar akademiyasi
Sahifa
504–508
Litsenziya
Ushbu ilmiy ish CC BY 4.0 litsenziyasi asosida ochiq.
Metadata manbasi
Partner conferences of the International Scientific Journal Research Focus
Oxirgi yangilanish
2026-08-25