Rifizostrep preparatining davolash va profilaktik samaradorligi

Maqolada VITI tuberkulyoz laboratoriyasi olimlari tomonidan yaratilgan Rifizostrep preparati bilan qishloq xo‘jalik hayvonlarining bakterial etiologiyali kasalliklarini davolash va profilaktika qilish uslubining ishlab chiqarishga joriy etish natijalari bayon qilingan. Mazkur uslubni tatbiq etilishi natijasida qishloq xo‘jalik hayvonlarining bakterial etiologiyali oftalmologik, respirator, ginekologik va jarroxlik kasalliklarini samarali davolash, shuningdek avitaminozlar profilaktikasini ta‘minlashga erishilgan

Vol. 5, Issue 8, 2026 ISSN 2181-3833 | Uzbekistan https://refocus.uz/

R E S E A R C H A R T I C L E • PEER-REVIEWED • OPEN ACCESS • HAC/OAK 16.00.00 — VETERINARY SCIENCES • UDC: 616:995.132.2:636.2:615.21

The therapeutic and preventive effectiveness of the drug Rifizostrep Rifizostrep preparatining davolash va profilaktik samaradorligi Лечебно-профилактическая эффективность препарата Рифизостреп Gulmurod Hamidovich MAMADULLAYEV1, Oybek Komiljonovich DJURAKULOV1, Siroj Gulmurodovich HAMIDOV1 Scientific-Research Institute of Veterinary, Samarkand, Uzbekistan

ARTICLE INFO AUTHOR, TITLE AND ABSTRACT METADATA (EN / UZ / RU)

ARTICLE TYPE Research Article ENGLISH LANGUAGE OF FULL TEXT Gulmurod Hamidovich MAMADULLAYEV1, Oybek Komiljonovich DJURAKULOV1, Siroj O‘zbekcha (UZ) Gulmurodovich HAMIDOV1 Scientific-Research Institute of Veterinary, Samarkand, Uzbekistan ☑ SCIENTIFIC FIELD / OAK 16.00.00 – Veterinary Sciences Veterinariya fanlari Abstract. The article presents the results of the introduction of a complex drug – Rifizostrep for the HAC Presidium decision No. 371/5, 13.06.2025 treatment and prevention of bacterial etiology diseases of farm animals developed by Scientific UDC / UDK Research Institute of Veterinary scientists. The introduction of this drug made it possible to 616:995.132.2:636.2:615.21 effectively cure of farm animals from diseases of the organs of sight, respiration, ginecological and surgical diseases of bacterial etiology and also the prevention of avitaminosis. Keywords: Rifizostrep; etiology; chemiciprofilacsis; strain; bacteriological; sinerjis; prolonges; ARTICLE HISTORY kombination; respirator; ginecological; oftalmological; avitaminosis; profilaxis Received: 2026-07-29 Revised: 2026-08-08 Accepted: 2026-08-13 O‘ZBEKCHA Published: 2026-08-31 MAMADULLAYEV Gulmurod Hamidovich1, DJURAKULOV Oybek Komiljonovich1, HAMIDOV Siroj Gulmurodovich1 Veterinariya ilmiy-tadqiqot instituti, Samarqand, O‘zbekiston DOI https://doi.org/10.66073/ReFocus.V5I8.0810 Annotatsiya. Maqolada VITI tuberkulyoz laboratoriyasi olimlari tomonidan yaratilgan Rifizostrep preparati bilan qishloq xo‘jalik hayvonlarining bakterial etiologiyali kasalliklarini davolash va profilaktika qilish uslubining ishlab chiqarishga joriy etish natijalari bayon qilingan. Mazkur uslubni tatbiq etilishi natijasida qishloq xo‘jalik hayvonlarining bakterial etiologiyali oftalmologik, CONTACT respirator, ginekologik va jarroxlik kasalliklarini samarali davolash, shuningdek avitaminozlar ReFocusJournal@gmail.com profilaktikasini ta’minlashga erishilgan Kalit so‘zlar: Rifizostrep; etiologiya; kimyoprofilaktika; shtamm; bakteriologiya; sinergetik; prolongatsiya; kombinatsiya; respirator; ginekologik; jarrohlik; oftalmologik; avitaminozlar; LICENSE profilaktika

Creative Commons Attribution 4.0 International (CC BY 4.0). This is an open access article distributed РУССКИЙ under the terms of the CC BY 4.0 licence. МАМАДУЛЛАЕВ Гулмурод Хамидович1, ДЖУРАКУЛОВ Ойбек Комилжонович1, ХАМИДОВ Сирож Гулмуродович1 Научно-исследовательский институт ветеринарии, Самарканд, Узбекистан

Аннотация. В статье приводятся результаты внедрения в производство комплексного препарата Рифизостреп для лечения и профилактики болезней бактериальной этиологии сельскохозяйственных животных разработанного учеными лаборатории по изучению туберкулёза НИИ ветеринарии. Внедрения данного препарата позволило эффективно вылечит сельскохозяйственных животных от болезней органов зрения, дыхания, гинекологических и хирургических болезней бактериалной этиологии, а также профилактики авитаминозов. Ключевые слова: Рифизостреп; этиология; химиопрофилактика; штамм; бактериология;

How to cite / Iqtibos keltirish / Как цитировать: MAMADULLAYEV, G. H., DJURAKULOV, O. K., HAMIDOV, S. G. (2026). The therapeutic and preventive effectiveness of the drug Rifizostrep. Research Focus International Scientific Journal, 5(8), [pp–pp]. https://doi.org/10.66073/ReFocus.V5I8.0810 © 2026 The Author(s). Published by Research Focus International Scientific Journal. Open access article under the CC BY 4.0 licence. HAC / OAK: On the HAC list of national scientific publications (Academy of Sciences of the Republic of Uzbekistan) for 06.00.00 Agricultural Sciences and 16.00.00 Veterinary Sciences. O‘zbekiston Respublikasi FA huzuridagi OAK ro‘yxatida: 06.00.00 – Qishloq xo‘jaligi fanlari; 16.00.00 – Veterinariya fanlari.

синергетик; пролонгация; комбинация; респиратор; гинекологический; хирургический; офтальмологический; авитаминозы; профилактика

1. KIRISH Hayvonlarni bakterial (kolibakterioz, salmonellez, pasterellez, Introduction leptospiroz, diplokokkoz va bsh.) yuqumli kasalliklarga qarshi Mavzuning dolzarbligi. Veterinariya ilmiy tadqiqot instituti emlangandan so‘ng, 14-21 kun davomida preparatni in’eksiya tuberkulyozni o‘rganish laboratoriyasi olimlari tomonidan qilish mumkin emas. Chunki, preparat tarkibidagi antibakterial tuberkulyoz qo‘zg‘atuvchilariga qarshi farmakopeya dorivorlardan preparatlar immonogenezga ta’sir ko‘rsatadi. tashkil topgan Rifizostrep preparati yaratilgan. Shakl beruvchi Preparatning optimal emlash dozalarini qabul qilgan element va adyuvant sifatida vitaminli o‘simlik moyi qo‘llanilgan. hayvonlardan olingan go‘sht va sut mahsulotlarini cheklovsiz Rifizostrep tarkibiga kiruvchi dorivorlarning turli iste’molga chiqarish mumkin. Organizm uchun preparat tomonidan mikroorganizmlarga bakteriostatik va bakteritsid ta’sirini inobatga nomutanosib ta’sir kuzatilmaydi. olib, preparatni har xil turdagi yuqumli va yuqumsiz kasalliklarni davolash samaradorligi ishlab ishlab chiqarish sharoitida tadqiq Hayvonlarga preparat yuborilgandan so‘ng in’eksiya joyida qilingan va ishlab chiqarishga joriy etilgan. og‘riqsiz shish hosil bo‘ladi va sekin organizmga so‘riladi. Organizm uchun preparat tomonidan boshqa nomutanosib ta’sir Qishloq xo‘jalik hayvonlarining respirator, ginekologik, kuzatilmaydi. Antidot yoki boshqa neytrallovchi dori vositalarga oftalmologik va jarrohlik kasalliklarini davolashda bir necha xil ehtiyoj yo‘q.. preparatlar, jumladan antibiotiklar, sulfanilamidlar, nitrofuran preparatlari va boshqa turdagi simptomatik preparatlar qo‘llaniladi. 3. NATIJALAR VA ULARNING TAHLILI Mazkur preparat qo‘llanilsa, boshqa turdagi preparatlarni Results and discussion qo‘llashga ehtiyoj tug‘ilmaydi. Tadqiqotlarning natijalari va ularning tahlili. Rifizostrep Rifizostrep preparati yordamida qishloq xo‘jalik hayvonlarining preparati bilan davolash uslubi yordamida qoramollar, qo‘ylar, otlar bakterial etiologiyali kasalliklarini davolash uslubi Respublika va cho‘chqalarning har xil turdagi bakterial etiologiyali yuqumli va chorvachilik xo‘jaliklarida tadbiq etilishi chet davlatlardan yuqumsiz kasalliklarini davolash samaradorligi ishlab ishlab keltiriladigan import preparatlarga qaramlikni kamaytirish chiqarish sharoitida tadqiq qilindi. Preparat yordamida respirator imkoniyatini yaratadi. (bronxit, bronxopnevmoniya), ginekologik (mastit, endometrit, metritlar), oftalmologik (blefarit, konyunktivit, 2. MATERIALLAR VA METODLAR keratokonyunktivit), jarrohlik kasalliklari (abssess, flegmona, Materials and methods jarrohlik operatsiyalari) muvaffaqiyatli davolandi, gipo- va Tadqiqotlarning hajmi, material va uslublari. Preparat avitaminozlar profilaktikasiga erishildi. tayyorlashning texnologik reglamenti ishlab chiqilgan. Respirator kasalliklarni davolash. Qishloq xo‘jalik Laboratoriya hayvonlari organizmida preparatning sterilligi, hayvonlarining respirator kasalliklarini Rifizostrep preparati bilan bezararligi, areaktogenligi, kasallikdan davolash samarasi, optimal davolash uchun dastlab tashqi va ichki nomaqbul etiologik qo‘llash dozalari, intervali va davomiyligi, chorvachilik ta’sirotlar bartaraf qilindi. Hayvonlarni saqlashning optimal xo‘jaliklarida qishloq xo‘jalik hayvonlarining turli kasalliklarni zoogigienik me’yorlari yaratildi. Birlamchi stress omillarga davolash samaradorligi aniqlangan. (yelvizak, ammiak gazi va namlik) barham berildi. Oziqa ratsioni Rifizostrep tarkibiga kiruvchi komponentlar keng doirali oqsil, uglevod, vitaminlar, makro- va mikroelementlar bilan antimikrob ta’siriga ega bo‘lib, farmakokinetikasi boyitildi. Har 2 kunda 1 marta teri ostidan 5,0 ml/100 kg vazni mikobakteriyalar, grammanfiy (ichak tayoqchalari, salmonellalar, hisobida kasal hayvonlarga preparat ineksiya qilindi. Qo‘shimcha klebsiellalar, tulyaremiya va bsh.) va ba’zi grammusbat ravishda binolar poli mexanik tozalanib, 3% formalin va 3% (stafilakokklar, pnevmokokklar, streptokokklar) o‘yuvchi natriy eritmalari bilan dezinfeksiya qilindi, joriy mikroorganizmlarga bakteritsid va bakteriostatik ta’sir ko‘rsatadi. ta’mirlash va 5% so‘ndirilgan ohak bilan oqlash ishlari yo‘lga Parenteral (teri ostiga) yuborilgan preparatning in’eksiya joyida qo‘yildi. depo hosil bo‘lib, sekin so‘riladi va organizmda 15-20 kundan Ilmiy ishlanmani joriy etish tadbirlari Samarqand viloyat Urgut so‘ng maksimal to‘planadi va 30 kungacha saqlanadi. tuman “Temur To‘lagan ko‘chat va nihollari” fermer xo‘jaligi Preparat tarkibiga kiruvchi komponentlarning o‘zaro qaramog‘idagi 20 bosh o‘tkir va surunkali bronxit, o‘tkir kombinatsiyasi -sinergetik (bir dori ta’sirini ikkinchisi bronxopnevmoniya bilan kasallangan buzoqlarga joriy etildi va 80- kuchaytirishi) va prolongatsiya (dorining ta’sir muddatini 100% davolash samaradorligiga erishildi. Shuningdek, Toshkent uzaytirishi) samarasini beradi. viloyat Toshkent tumanidagi “Mehnat Baxtli Sut” MChJ-ga qarashli chorvachilik fermasida 64 bosh buzoqlar nafas olish tizimi Preparat hayvonlarning o‘ng yoki chap tomon bo‘yin qismiga, kasalliklaridan rifizostrep preparati yordamida davolandi. kurak-yelka bo‘g‘inidan 10-15 sm old tomoniga va to‘shlik qismi teri ostiga yuboriladi. Ginekologik, oftalmologik va jarrohlik Ginekologik kasalliklarni davolash. Chorvachilik xo‘jaliklari kasalliklarida jarohat va yallig‘lanish joyiga tomiziladi. fermalarida sigirlarni ginekologik kasalliklardan davolash uchun Preparatning bir marta ineksiya qilish dozasi hayvonlarning tirik dastlab bachadon bo‘shlig‘i yot moddalardan mexanik tozalandi, vazniga ko‘ra, har 100 kg vaznga 5 ml hisobida teri ostiga dezinfeksiyalovchi eritmalar yordamida yuvib olindi. So‘ngra qo‘llaniladi. Tirik vazni 400 kg va undan yuqori hayvonlarga 20 ml. bachadon bo‘shlig‘iga har bir sigirga 20-ml rifizostrep shpris dan ortiq yuborish mumkin emas. Preparatni jarohat joyiga katetor yordamida yuborildi. Bu protsedura 5-6 kun ichida 2-3 tomizish yallig‘lanish darajasi va lokalizatsiyalangan organizm marta takrorlandi. Sigirning umumiy ahvoligi ko‘ra, boshqa ichki-a’zosiga bog‘liq bo‘lib, 1-2 ml dan 20 ml gacha yuborish konservativ davolash muolajalari qilish mumkin. Bo‘yin terisi mumkin. Masalan, ko‘z orbitasiga 1-2 ml tomizilsa, bachadon ostidan 5 ml/100 kg dozada preparat yuborildi. Natijada barcha bo‘shlig‘iga 20 ml gacha, jarrohat joyiga 5-20 ml tomiziladi. sigirlar endometrit va metritdan kasalligidan davolandi. Bundan Preparatni 10 kunlik yoshdan boshlab fiziologik holatidan qat’iy tashqari, ishlab chiqarish sharoitidagi kuzatuvlarimizga ko‘ra, nazar barcha turdagi hayvonlarga qo‘llash mumkin. profilaktik maqsadda rifizostrep qabul qilgan sigirlarda bug‘ozlik davrida bachadondagi buzoqning normal rivojlanishi kuzatilib,

buzoqlar sog‘lom va harakatchan bo‘lib tug‘ildi. Hayvonlarni tulyaremiya va b.sh.) va ba’zi grammusbat (stafilakokklar, ginekologik kasalliklardan davolash samaradorligi 80-90 %-ni pnevmokokklar, streptokokklar) mikroorganizmlarga bakteritsid va tashkil qildi. bakteriostatik ta’sir ko‘rsatadi; Gipo va avitaminozlar profilaktikasi. Chorvachilik fermalarida Rifizostrep preparati bilan davolash uslubi yordamida qishloq ba’zan qoramollar organizmida ayrim vitaminlar yetishmasligi xo‘jalik hayvonlarining respirator (bronxit, bronxopnevmoniya), sababli, poligipovitaminozlar uchraydi va yaqqol klinik belgilar ginekologik (mastit, metrit), oftalmologik (blefarit, konyunktivit, kuzatilmaydi. Natijada hayvon organizmi o‘sishdan orqada qoladi, keratokonyunktivit), jarrohlik kasalliklari (abssess, flegmona, mahsuldorlik kamayib ketadi, kasalliklarga chalinuvchanligi jarrohlik operatsiyalari) muvaffaqiyatli davolandi, gipo- va kuchayadi. Preparat tarkibidagi A, D va Ye vitaminlar chorvachilik avitaminozlar profilaktikasiga erishildi; fermalarida hayvonlar organizmidagi avitaminoz va Rifizostrep preparati bilan qishloq xo‘jalik hayvonlarining gipovitaminozlarning oldini olishga xizmat qiladi. Uslubiy kasalliklarini davolashning yangi uslubi ishlab chiqildi va Tavsiyanomagaa muvofiq joriy etilgan rifizostrep preparati qishloq preparatni ineksiya qilish, ko‘zga tomizish, jarohat joyiga surtish, xo‘jalik hayvonlari organizmida avitaminozlar profilaktikasini yiringli jarohatlarda drenaj sifatida qo‘llanilishi ijobiy terapevtik ta’minladi. samara berishi aniqlandi. Oftalmologik kasalliklarni davolash: Xo‘jaliklar sut tovar fermalari binolarida polning notekisligi va sifatsiz mexanik DECLARATIONS tozalash tufayli bino ichida ammiak gazi miqdori va namlik oshib Declarations ketishi sababli buzoqlarda blefarit, keratit va keratokonyunktivit kasalliklari tarqaladi. Author contributions CRediT Rifizostrep preparati yordamida ko‘z kasalliklarini davolash Conceptualization; Methodology; Investigation; Data curation; uchun kasal hayvonlarni saqlash joyi o‘zgartirildi va optimal Writing – original draft; Writing – review & editing. All authors have read and agreed to the published version of the manuscript. zoogigienik sharoit yaratildi. Oziqlantirish ratsioni kuchaytirildi. Davolash protseduralari o‘tkazish uchun konyunktiva xaltasiga 3-4 Funding tomchi rifizostrep har kuni 1 marta tomizildi. 2-3 marta preparat This research received no external funding. tomizilgandan so‘ng hayvonlar davolandi. Zaruratga ko‘ra, preparatni ineksiya ham qilish mumkin. Ethics approval Not applicable. This study did not involve humans, animals or other Mexanik jarohat tufayli hayvonlarda ko‘z orbitasi shishadi, regulated materials. biriktiruvchi to‘qima qobig‘i giperemiyaga uchraydi, qon quyiladi, seroz yoki yiringli zardob oqadi. Ba’zan qishloq xo‘jalik Informed consent hayvonlarida ko‘z orbitasi oq rangli plyonka bilan qoplanadi va All authors have read and approved the final version of the manuscript ko‘zi ko‘r bo‘lib qoladi. Bunday hayvonlarni davolash uchun ko‘z and have given their consent to its submission and publication. The konyunktiva xaltasi 3% bor kislotasi bilan yuvildi. So‘ngra study involved no human participants and no personal data. konyunktiva xaltasiga 5-6 tomchi rifizostrep suspenziyasi Data availability statement tomizildi. Zaruratga ko‘ra, ineksiya ham qilindi. 3-4 marta ishlov All data supporting the findings of this study are presented in the berilgandan so‘ng hayvonlarning ko‘zi 100% davolandi. Preparatni article and are available from the corresponding author upon joriy etilishi natijasida ko‘z kasalliklari bilan kasallangan hayvonlar reasonable request. muvaffaqiyatli davolandi. Conflict of interest Jarrohlik kasalliklarini davolash. Chorvachilik fermalarida The authors declare no conflict of interest. qishloq xo‘jalik hayvonlari orasida turli xil mexanik-travmatik jarohatlar uchrab turadi. Mexanik jaroxat lokalizatsiyalangan joyda Generative AI disclosure turli stafilokokklar, streptokokklar va boshqa bakteriyalar Generative AI was used only partially. The authors used Claude rivojlanadi va natijada hayvon tanasida yiringli o‘choqlar hosil (Anthropic, Opus 5) for language editing, formatting of the reference bo‘ladi. Abssess, flegmona kabi jarohatlarni rifizostrep preparati list and preparation of the English and Russian metadata. No text, qo‘llash yordamida davolash protseduralari o‘tkazish ijobiy samara data, figures or conclusions were generated by AI. The authors berdi. Jumladan, qishloq xo‘jalik hayvonlarida gavda sohasida turli reviewed and verified all output and take full responsibility for the joyda jaylashadigan abssess, flegmonalar ushbu preparatni qo‘llash content of the publication. orqali muvaffaqiyatli davolandi. EXTENDED SUMMARY IN ENGLISH Buning uchun jarohat joyidagi ekssudat, sekvestr va nekrozga uchragan to‘qima jarroxlik usulida mexanik tozalandi, jarohat Kengaytirilgan inglizcha xulosa / Расширенный реферат на английском языке bo‘shlig‘iga drenaj yordamida preparat qo‘llanildi, qo‘shimcha ineksiya ham qilindi. Preparatni joriy etish tadbirlari shuni Mandatory for all articles whose full text is not in English. Length 600–1000 words. It must be independently readable: a reader who does not know the ko‘rsatdiki, jarrohlik kasalliklarini davolashda yuqori terapevtik va language of the full text should understand the problem, the method, the antiseptik samara berdi va kasal hayvonlarda 2-3 kun ichida numerical results and the contribution without consulting the main text. Do not granulyatsion to‘qima o‘sishi va jarohatning sog‘ayishi kuzatildi. copy the 250-word abstract. Davolash samaradorligi 90-100%. ni tashkil qildi. Purpose and research problem Bacterial diseases of farm animals — respiratory, gynaecological, 4. XULOSALAR Conclusions ophthalmological and surgical — are normally treated with a range of separate agents: antibiotics, sulfonamides, nitrofurans and various Rifizostrep preparati tarkibiga kiruvchi komponentlar keng symptomatic preparations. This multiplicity of products increases the doirali antimikrob ta’sirga ega; Preparat tarkibiga kiruvchi cost of treatment and, in the conditions of Uzbekistan, the dependence komponentlarning o‘zaro kombinatsiyasi - sinergetik (bir dori on imported medicines. Scientists of the tuberculosis research ta’sirini ikkinchisi kuchaytirishi) va prolongatsiya (dorining ta’sir laboratory of the Scientific-Research Institute of Veterinary developed muddatini uzaytirishi) xususiyatini berdi; Rifizostrep, a complex preparation composed of pharmacopoeial agents active against the causative agents of tuberculosis, in which a Rifizostrep preparatning farmakokinetikasi mikobakteriyalar, vitamin-containing vegetable oil serves both as the shaping element grammanfiy (ichak tayoqchalari, salmonellalar, klebsiellalar, and as an adjuvant. Given the bacteriostatic and bactericidal action of

its components against a broad range of microorganisms, the aim of bactericidally and bacteriostatically on mycobacteria, on Gramthe work was to study, under production conditions, the effectiveness negative and on certain Gram-positive microorganisms. Using this of Rifizostrep in the treatment and prevention of bacterial diseases of method, respiratory (bronchitis, bronchopneumonia), gynaecological farm animals and to introduce the corresponding method into practice. (mastitis, metritis), ophthalmological (blepharitis, conjunctivitis, keratoconjunctivitis) and surgical conditions (abscess, phlegmon, Materials and methods surgical operations) of farm animals were successfully treated and the A technological regulation for the manufacture of the preparation was prevention of hypo- and avitaminoses was achieved. A new method of developed. In laboratory animals the sterility, harmlessness and treating bacterial diseases of farm animals with Rifizostrep was areactogenicity of the preparation were established, together with its developed, and its administration by injection, instillation into the eye, therapeutic effect, optimal doses, interval and duration of application to the wound surface and use as a drain in purulent administration; the effectiveness against various diseases of farm wounds was shown to give a positive therapeutic effect. The practical animals was then determined on livestock farms. The components of contribution of the work is a single domestically produced preparation Rifizostrep possess a broad antimicrobial spectrum and act that replaces several imported agents across four groups of disease and bactericidally and bacteriostatically on mycobacteria, on Gram- reduces the dependence of the national livestock sector on imported negative organisms (Escherichia, Salmonella, Klebsiella, the agent of medicines. tularaemia and others) and on some Gram-positive organisms (staphylococci, pneumococci, streptococci). After parenteral