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DEVELOPMENT OF IONOPHORES FOR ION-SELECTIVE ELECTRODES FOR THE DETERMINATION OF MEDICINAL SUBSTANCES.

Ulug‘murotova Gulhayo Shuhrat qizi1, Abdurahmonova Z. E.22025

  1. 1student of the Faculty of Medical Biology of Samarkand State Medical University
  2. 2assistant of Samarkand State Medical University.

JurnalResearch Focus International Scientific JournalJild 4Son 4Sahifa 237–243

Annotatsiya

Ushbu maqolada dori vositalarini aniqlash uchun ionselektiv elektrodlar (ISE) ishlab chiqishda qo‘llaniladigan yangi ionoforlar sintezi va ularning xossalari o‘rganildi. Tadqiqotda dododekowolframofosfat va dodekomolibdofosfat kislotalari asosida dibazol, trimekain hamda piridoksin preparatlari uchun selektiv ionoforlar yaratildi. Sintez jarayonlari, elektrod tayyorlash usullari, eritmalar konsentratsiyasi va pH ta‘siri chuqur tahlil qilindi. Ushbu usullar arzon, oson bajariladigan va yuqori aniqlikka ega bo‘lib, farmatsevtik analizda keng qo‘llanilishi mumkin. Olingan natijalar asosida yangi selektiv elektrodlar ishlab chiqishning amaliy ahamiyati asoslab berildi.

Boshqa tillarda

inglizchaDEVELOPMENT OF IONOPHORES FOR ION-SELECTIVE ELECTRODES FOR THE DETERMINATION OF MEDICINAL SUBSTANCES.

This article studies the synthesis and the properties of new ionophores used in the development of ion-selective electrodes (ISE) for the detection of drugs. In the course of the research, selective ionophores were created for the preparations dibazol, trimecaine and pyridoxine on the basis of dodecatungstophosphoric and dodecamolybdophosphoric acids. The synthesis processes, the methods of electrode preparation, the concentration of the solutions and the influence of pH were analysed in depth. These methods are inexpensive, easy to perform and highly accurate, and can therefore be widely applied in pharmaceutical analysis. On the basis of the results obtained, the practical significance of developing new selective electrodes was substantiated.

o‘zbekDORI VOSITALARINI ANIQLASH UCHUN IONSELEKTIV ELEKTRODLAR UCHUN IONOFORLARNI ISHLAB CHIQISH.

Ushbu maqolada dori vositalarini aniqlash uchun ionselektiv elektrodlar (ISE) ishlab chiqishda qo‘llaniladigan yangi ionoforlar sintezi va ularning xossalari o‘rganildi. Tadqiqotda dododekowolframofosfat va dodekomolibdofosfat kislotalari asosida dibazol, trimekain hamda piridoksin preparatlari uchun selektiv ionoforlar yaratildi. Sintez jarayonlari, elektrod tayyorlash usullari, eritmalar konsentratsiyasi va pH ta‘siri chuqur tahlil qilindi. Ushbu usullar arzon, oson bajariladigan va yuqori aniqlikka ega bo‘lib, farmatsevtik analizda keng qo‘llanilishi mumkin. Olingan natijalar asosida yangi selektiv elektrodlar ishlab chiqishning amaliy ahamiyati asoslab berildi.

ruschaРАЗРАБОТКА ИОНОФОРОВ ДЛЯ ИОНСЕЛЕКТИВНЫХ ЭЛЕКТРОДОВ ДЛЯ ОБНАРУЖЕНИЯ НАРКОТИКОВ

В данной статье изучаются синтез и свойства новых ионофоров, используемых при разработке ионселективных электродов (ИСЭ) для обнаружения наркотиков. В результате исследования созданы селективные ионофоры для препаратов дибазола, тримекаина и пиридоксина на основе дододецилвольфрамовой кислоты и додецилмолибдофосфата. Были подробно проанализированы процессы синтеза, методы подготовки электродов, концентрация раствора и влияние pH. Эти методы недороги, просты в исполнении и высокоточны, поэтому их можно широ ко использовать в фармацевтическом анализе. На основании полученных результатов обоснована практическая значимость разработки новых селективных электродов.

Kalit so‘zlar

  • Ion-selective electrodes
  • ionophore
  • heteropolyacids
  • dodecatungstophosphate
  • dodecamolybdophosphate
  • dibazol
  • trimecaine
  • pyridoxine
  • pharmaceutical analysis
  • selectivity

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Metama’lumot

Identifikator
REL-A-012918
Nashr sanasi
2025-05-05
Til
inglizcha
Jurnal
Research Focus International Scientific Journal
Jild
4
Son
4
DOI
10.66073/researchfocus.v4i4.1587
ISSN
2181-3833 · 2181-3833
Nashriyot
LLC Ilm-fan va innovatsiyalar akademiyasi
Sahifa
237–243
Litsenziya
Ushbu ilmiy ish CC BY 4.0 litsenziyasi asosida ochiq.
Ko‘rishlar
62026-10-10 dan beri o‘lchanmoqda
Metadata manbasi
Research Focus International Scientific Journal
Oxirgi yangilanish
2026-09-11