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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">research-focus</journal-id>
      <journal-title-group>
        <journal-title>Research Focus International Scientific Journal</journal-title>
        <abbrev-journal-title abbrev-type="publisher">Research Focus</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="epub" publication-format="electronic">2181-3833</issn>
      <publisher>
        <publisher-name>Ilm-fan va innovatsiyalar akademiyasi</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.66073/researchfocus.v1i4.2926</article-id>
      <article-id pub-id-type="other" assigning-authority="relibrary.uz">REL-A-013862</article-id>
      <title-group>
        <article-title xml:lang="en">INFLUENCE OF GESTATION DATE ON THE SEVERITY OF HYPOXIC-ISCHEMIC ENCEPHALOPATHY IN NEWBORN</article-title>
        <trans-title-group xml:lang="ru">
          <trans-title>ВЛИЯНИЕ СРОКА ГЕСТАЦИИ НА СТЕПЕНЬ ТЯЖЕСТИ ГИПОКСИЧЕСКИ-ИШЕМИЧЕСКОЙ ЭНЦЕФАЛОПАТИИ У НОВОРОЖДЁННЫХ</trans-title>
        </trans-title-group>
        <trans-title-group xml:lang="uz">
          <trans-title>YANGI TUG‘ILGAN CHAQALOQLARDA GESTATSIYA MUDDATINING GIPOKSIK-ISHEMIK ENSEFALOPATIYA OG‘IRLIK DARAJASIGA TA‘SIRI</trans-title>
        </trans-title-group>
      </title-group>
      <contrib-group content-type="author">
        <contrib contrib-type="author">
          <string-name>Ibragimova Nadiya Sabirovna</string-name>
          <aff>Assistant, Department of Clinical and Laboratory Diagnostics with the Course of Clinical and Laboratory Diagnostics of the Faculty of Postgraduate Education, Samarkand State Medical University, Republic of Uzbekistan, city of Samarkand</aff>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Diamatova Dinora Norkobil qizi</string-name>
          <aff>Clinical resident, Department of Clinical and Laboratory Diagnostics with the Course of Clinical and Laboratory Diagnostics of the Faculty of Postgraduate Education, Samarkand State Medical University, Republic of Uzbekistan, city of Samarkand</aff>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Rajabov Nodir Ural o‘g‘li</string-name>
          <aff>Student, Department of Clinical and Laboratory Diagnostics with the Course of Clinical and Laboratory Diagnostics of the Faculty of Postgraduate Education, Samarkand State Medical University, Republic of Uzbekistan, city of Samarkand</aff>
        </contrib>
      </contrib-group>
      <pub-date publication-format="electronic" date-type="pub" iso-8601-date="2023-01-05">
        <day>05</day>
        <month>01</month>
        <year>2023</year>
      </pub-date>
      <pub-date date-type="collection">
        <year>2022</year>
      </pub-date>
      <volume>1</volume>
      <issue>4</issue>
      <fpage>48</fpage>
      <lpage>51</lpage>
      <permissions>
        <license xlink:href="https://creativecommons.org/licenses/by/4.0">
          <ali:license_ref>https://creativecommons.org/licenses/by/4.0</ali:license_ref>
          <license-p>This work is licensed under a Creative Commons Attribution 4.0 International License.</license-p>
        </license>
      </permissions>
      <self-uri xlink:href="https://relibrary.uz/REL-A-013862/"/>
      <abstract xml:lang="en">
        <p>Identification of the leading cause of CNS dysfunction in a newborn, even with a thorough examination, is often a difficult task. The nature and depth of the pathological process in the brain and spinal cord remain unclear, neurological disorders are dynamic, and an accurate prediction of further development is difficult. In this regard, the use of the terms &quot;encephalopathy&quot; is justified, to refer to &quot;transient and unclassified pathological conditions of the central nervous system.&quot; Despite the progress of perinatal medicine, hypoxic-ischemic encephalopathy remains an important cause of infant mortality and damage to the central nervous system, leading to disability in children.</p>
      </abstract>
      <trans-abstract xml:lang="ru">
        <p>Выделение ведущей причины нарушения деятельности ЦНС у новорожденного даже при тщательном его обследовании является нередко сложной задачей. Характер и глубина патологического процесса в головном, спинном мозге остаются неясными, неврологические нарушения динамичны, точный прогноз дальнейшего развития затруднителен. В связи с этим оправдано использование терминов «энцефалопатия», для обозначения «преходящих и неклассифицированных патологических состояний ЦНС». Несмотря на прогресс перинатальной медицины, гипоксически-ишемическая энцефалопатия остаётся важной причиной детской смертности и повреждения центральной нервной системы, приводящей к инвалидности детей.</p>
      </trans-abstract>
      <trans-abstract xml:lang="uz">
        <p>Yangi tug‘ilgan chaqaloqda MNT faoliyati buzilishining yetakchi sababini aniqlash, hatto sinchiklab tekshirilganda ham, ko‘pincha qiyin vazifa hisoblanadi. Bosh va orqa miyadagi patologik jarayonning tabiati va chuqurligi noaniqligicha qolmoqda, nevrologik buzilishlar dinamik bo‘lib, keyingi rivojlanishni aniq bashorat qilish qiyin. Shu munosabat bilan &quot;markaziy nerv tizimining o‘tkinchi va tasniflanmagan patologik holatlari&quot;ni ifodalash uchun &quot;ensefalopatiya&quot; atamalarini qo‘llash asoslidir. Perinatal tibbiyotdagi yutuqlarga qaramay, gipoksik-ishemik ensefalopatiya go‘daklar o‘limi hamda bolalarda nogironlikka olib keluvchi markaziy nerv tizimi shikastlanishining muhim sababi bo‘lib qolmoqda.</p>
      </trans-abstract>
      <kwd-group xml:lang="en">
        <kwd>hypoxic-ischemic encephalopathy</kwd>
        <kwd>newborns</kwd>
        <kwd>gestational age</kwd>
        <kwd>severity</kwd>
        <kwd>clinical symptoms</kwd>
      </kwd-group>
      <kwd-group xml:lang="ru">
        <kwd>гипоксически-ишемическая энцефалопатия</kwd>
        <kwd>новорождённые</kwd>
        <kwd>сроки гестации</kwd>
        <kwd>степени тяжести</kwd>
        <kwd>клиниченская симптоматика</kwd>
      </kwd-group>
      <kwd-group xml:lang="uz">
        <kwd>gipoksik-ishemik ensefalopatiya</kwd>
        <kwd>yangi tug‘ilgan chaqaloqlar</kwd>
        <kwd>gestatsiya muddati</kwd>
        <kwd>og‘irlik darajasi</kwd>
        <kwd>klinik simptomlar</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <back>
    <ref-list>
      <ref id="r1">
        <label>1</label>
        <mixed-citation>Зарубин А.А., Михеева Н.И., Филиппов Е.С., Белогорова Т.А., Ваняркина А.С., Шишкина А.А. ГИПОКСИЧЕСКИ-ИШЕМИЧЕСКАЯ ЭНЦЕФАЛОПАТИЯ У НОВОРОЖДЁННЫХ, РОЖДЁННЫХ В ТЯЖЁЛОЙ АСФИКСИИ. Acta Biomedica Scientifica. 2017;2(2):95-101.</mixed-citation>
      </ref>
      <ref id="r2">
        <label>2</label>
        <mixed-citation>Пальчик А.Б., Шабалов Н.П. Гипоксически-ишемическая энцефалопатия новорожденных. -Санкт-Петербург: Питер, 2000. - 219с.</mixed-citation>
      </ref>
      <ref id="r3">
        <label>3</label>
        <mixed-citation>Kudratova Z. E. et al. The Role of Cytokine Regulation in Obstructive Syndrome of Atypical Genesis in Children //Annals of the Romanian Society for Cell Biology. – 2021. – С. 6279–6291-6279–6291.</mixed-citation>
      </ref>
      <ref id="r4">
        <label>4</label>
        <mixed-citation>Бердиярова Ш.Ш., Юсупов Ш.А., Назарова Г.Ш. &quot;КЛИНИКО-ЛАБОРАТОРНЫЕ ОСОБЕННОСТИ ХРОНИЧЕСКОГО ГЕМАТОГЕННОГО ОСТЕОМИЕЛИТА&quot;. //Central Asian Research Journal For Interdisciplinary Studies (CARJIS) Issue 5 | May, 2022. (116-125 ст)</mixed-citation>
      </ref>
      <ref id="r5">
        <label>5</label>
        <mixed-citation>Mansurov T. T., Daminov F. A. Complex Diagnosis and Treatment of Patients with Acute Adhesive Intestinal Obstruction //British Medical Journal. – 2022. – Т. 2. – №. 1.</mixed-citation>
      </ref>
      <ref id="r6">
        <label>6</label>
        <mixed-citation>Даминов Ф. А. и др. Синдром кишечной недостаточности и его коррекция у тяжелообожженных //Журнал Неотложная хирургия им. ИИ Джанелидзе. – 2021-№. S1. – С. 20-21.</mixed-citation>
      </ref>
      <ref id="r7">
        <label>7</label>
        <mixed-citation>Nabieva F.S., Umarova S.S., Ruzmetova. S.U. Use of Saccharomyces cerevisiae for obtaining conjugates for ELISA //Thematics Journal of Microbiology. – 2022. -Т. 6.- №. 1.</mixed-citation>
      </ref>
      <ref id="r8">
        <label>8</label>
        <mixed-citation>Ruziboev S. A., Daminov F. A. OUR EXPERIENCE IN TREATMENT OF STRESS ULTRASONS IN SEVERE BURNED //Euro-Asia Conferences. – 2021. – Т.1.–№.1.–С.447-449.</mixed-citation>
      </ref>
      <ref id="r9">
        <label>9</label>
        <mixed-citation>Бердиярова, Шохида Шукуруллаевна, Юсупов Шухрат Абдурасулович, and Юсупова Наргиза Абдикодировна. &quot;КЛИНИКО-ЛАБОРАТОРНАЯ ХАРАКТЕРИСТИКА ХРОНИЧЕСКОГО ГЕМАТОГЕННОГО ОСТЕОМИЕЛИТА.&quot; //Вестник науки и образования 10-2 (113) (2021): 63-66.</mixed-citation>
      </ref>
      <ref id="r10">
        <label>10</label>
        <mixed-citation>Набиева Ф.C., Ибрагимова Н. С. Бобокулов О. О. Использование Saccharomyces cerevisiae для получения конъюгатов для ИФА (литературный обзор) //Журнал Биомедицины и практики. – 2022. – Т. 7. – №. 3.</mixed-citation>
      </ref>
      <ref id="r11">
        <label>11</label>
        <mixed-citation>НА ЮСУПОВА, ШШ БЕРДИЯРОВА, ИА ЮЛАЕВА, КА Гуломивич UROLITIAZDA BOLALARDA KLINIK-LABORATOR KO&apos;RSATKICHLAR VA STATSIONAR DAVOLASH BOSQICHIDA LABORATOR DIAGNOSTIKA SIFATI //ЖУРНАЛ БИОМЕДИЦИНЫ И ПРАКТИКИ -2022-7 (1)</mixed-citation>
      </ref>
      <ref id="r12">
        <label>12</label>
        <mixed-citation>Бердиярова Ш.Ш., and Юсупова Н.А. &quot;АЛКОГОЛЛИ ВА ВИРУСЛИ ГЕПАТИТ УЧУН БАЪЗИ ЛАБОРАТОРИЯ КЎРСАТКИЧЛАРИНИ ТАҚҚОСЛАШ ТАҲЛИЛИ.&quot; // Журнал гепато-гастроэнтерологических исследований 1, no. 3 (2020): 20-23.</mixed-citation>
      </ref>
      <ref id="r13">
        <label>13</label>
        <mixed-citation>Yusupova N., Firdavs O. Energy drinks. The composition of energy drinks and the effect on the body of their individual components //Thematics Journal of Microbiology. – 2022. – Т. 6. – №. 1.</mixed-citation>
      </ref>
      <ref id="r14">
        <label>14</label>
        <mixed-citation>Abdikadirova N. Y. et al. Clinical and laboratory parameters in children with urolithiasis and the Quality of laboratory tests at the stage of stationary treatment //Annals of the Romanian Society for Cell Biology. – 2021. – С. 7002-7012.</mixed-citation>
      </ref>
      <ref id="r15">
        <label>15</label>
        <mixed-citation>Eshqobilova Surayyo, Nargiza Yusupova, Oripov Firdavs. INFLUENCE OF ENERGY DRINKS ON INDIVIDUAL SYSTEMS OF THE HUMAN BODY //International Journal of Early Childhood Special Education, - 2022 - № - 14-5 P.7176-7184</mixed-citation>
      </ref>
      <ref id="r16">
        <label>16</label>
        <mixed-citation>Nabieva F.S., Rayimova F.S., Abdusamatov B.A. Artificial intelligence in medicine //Web of Scientist: International Scientific Research Journal. – 2022. – Т. 3. – №. 5. – С. 23-27.</mixed-citation>
      </ref>
      <ref id="r17">
        <label>17</label>
        <mixed-citation>Berdiyarova Sh.Sh., Yusupova N. A., Murtazaeva N. K., and Ibragimova N. S..&quot;Clinical and laboratory features of chronic hematogenic osteomyelitis&quot;. // Thematics Journal of Microbiology 6, no. 1 (2022).</mixed-citation>
      </ref>
      <ref id="r18">
        <label>18</label>
        <mixed-citation>Nabieva F.S. et al. Prospects for Developing Modifications of Methods for Producing Conjugates for Elisa //Annals of the Romanian Society for Cell Biology. – 2021. – С. 4120-4125.</mixed-citation>
      </ref>
      <ref id="r19">
        <label>19</label>
        <mixed-citation>Kudratova Z. E. et al. МЕДИЦИНСКИЕ НАУКИ PRINCIPLES OF THERAPY OF CHLAMYDIAL AND //Вопросы науки и образования. – С. 23.</mixed-citation>
      </ref>
      <ref id="r20">
        <label>20</label>
        <mixed-citation>Erkinovna K. Z., Berdirasulovich K. G., Andreevna Y. I. THE IMPORTANCE OF SOME LABORATORY INDICATORS IN LUNG DISEASES //Вестник науки и образования. – 2020. – №. 22-2 (100). – С. 70-72.</mixed-citation>
      </ref>
      <ref id="r21">
        <label>21</label>
        <mixed-citation>Erkinovna K. Z. et al. Bronchial obstruction syndrome in young children with respiratory infections of different etiology: features of clinical manifestations and immune response //Проблемы науки. – 2021. – №. 1 (60). – С. 60-62.</mixed-citation>
      </ref>
      <ref id="r22">
        <label>22</label>
        <mixed-citation>Mansurov T. T., Daminov F. A. ANALYSIS OF THE RESULTS OF THE POSSIBILITY OF VIDEOLAPAROSCOPY IN THE DIAGNOSTICS AND TREATMENT OF ACUTE INTESTINAL OBSTRUCTION //Art of Medicine. International Medical Scientific Journal. –2022. –Т. 2.–№.1.</mixed-citation>
      </ref>
    </ref-list>
  </back>
</article>
