<?xml version="1.0" encoding="utf-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD with MathML3 v1.3 20210610//EN" "JATS-journalpublishing1-3-mathml3.dtd">
<article xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.3" xml:lang="en">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">research-focus</journal-id>
      <journal-title-group>
        <journal-title>Research Focus International Scientific Journal</journal-title>
        <abbrev-journal-title abbrev-type="publisher">Research Focus</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="epub" publication-format="electronic">2181-3833</issn>
      <publisher>
        <publisher-name>Ilm-fan va innovatsiyalar akademiyasi</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.66073/refocus.v5i7.0704</article-id>
      <article-id pub-id-type="other" assigning-authority="relibrary.uz">REL-A-013533</article-id>
      <article-categories>
        <subj-group subj-group-type="oak">
          <subject>16.00.00</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title xml:lang="en">Clinical symptoms, seasonal dynamics and diagnosis of eimeriosis</article-title>
        <trans-title-group xml:lang="ru">
          <trans-title>Клинические симптомы, сезонная динамика и диагностика эймериоза</trans-title>
        </trans-title-group>
        <trans-title-group xml:lang="uz">
          <trans-title>Eymeriozning klinik belgilari, mavsumiy dinamikasi va diagnostikasi</trans-title>
        </trans-title-group>
      </title-group>
      <contrib-group content-type="author">
        <contrib contrib-type="author">
          <name>
            <surname>ABBOSOV</surname>
            <given-names>U. M.</given-names>
          </name>
          <aff>Scientific-Research Institute of Veterinary, Uzbekistan</aff>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>KHUSHNAZAROV</surname>
            <given-names>A. Kh.</given-names>
          </name>
          <aff>Scientific-Research Institute of Veterinary, Uzbekistan</aff>
        </contrib>
      </contrib-group>
      <pub-date publication-format="electronic" date-type="pub" iso-8601-date="2026-08-05">
        <day>05</day>
        <month>08</month>
        <year>2026</year>
      </pub-date>
      <pub-date date-type="collection">
        <year>2026</year>
      </pub-date>
      <volume>5</volume>
      <issue>7</issue>
      <fpage>31</fpage>
      <lpage>35</lpage>
      <permissions>
        <license xlink:href="https://creativecommons.org/licenses/by/4.0">
          <ali:license_ref>https://creativecommons.org/licenses/by/4.0</ali:license_ref>
          <license-p>This work is licensed under a Creative Commons Attribution 4.0 International License.</license-p>
        </license>
      </permissions>
      <self-uri xlink:href="https://relibrary.uz/REL-A-013533/"/>
      <abstract xml:lang="en">
        <p>This article presents the clinical signs of eimeriosis in farm animals, especially rabbits, the characteristics of the course of the disease, its outcomes and age-related data. The occurrence of the disease in rabbits by season, the results of observations on farms, the classical methods widely used for diagnosing the disease and the order of their implementation are described in sequence. In addition, guidance is given on identifying rabbits affected or unaffected by eimeriosis from their appearance, on taking anamnesis data and on performing palpation. The main information in the article was obtained by analysing literature sources and is presented in a consolidated form.</p>
      </abstract>
      <trans-abstract xml:lang="ru">
        <p>В данной статье представлены клинические признаки, особенности течения заболевания, последствия и возрастные данные по эймериозу у сельскохозяйственных животных, в частности у кроликов. Последовательно описаны заболеваемость кроликов по сезонам, результаты наблюдений на фермах, классические методы, широко используемые для диагностики заболевания, и порядок их применения. Кроме того, даны рекомендации по выявлению кроликов, инфицированных или не инфицированных эймериями, по внешнему виду, по сбору анамнеза и проведению пальпаторных методов. Основная информация статьи получена в результате анализа литературных источников и представлена в обобщённом виде.</p>
      </trans-abstract>
      <trans-abstract xml:lang="uz">
        <p>Ushbu maqolada qishloq xo‘jaligi hayvonlarida, ayniqsa quyonlarda uchraydigan eymeriozlarning klinik belgilari, kasallikning kechish xususiyatlari, oqibatlari va yoshga bog‘liq ma‘lumotlar keltirilgan. Quyonlarda kasallikning yil fasllariga qarab uchrash holati, xo‘jaliklardagi kuzatishlar natijalari, kasallikni aniqlashda keng qo‘llaniladigan klassik usullar va ularni bajarish tartibi ketma-ketlikda bayon qilingan. Bulardan tashqari, eymerioz bilan zararlangan yoki zararlanmagan quyonlarni tashqi ko‘rinishidan aniqlash, anamnez ma‘lumotlarini olish va paypaslash usullarini bajarish bo‘yicha yo‘riqnomalar keltirilgan. Maqoladagi asosiy ma‘lumotlar adabiyot manbalaridan tahlil qilib olingan va mujassamlashtirilgan holda taqdim etilgan.</p>
      </trans-abstract>
      <kwd-group xml:lang="en">
        <kwd>eimeriosis</kwd>
        <kwd>rabbit</kwd>
        <kwd>oocyst</kwd>
        <kwd>protozoa</kwd>
        <kwd>schizogony</kwd>
        <kwd>gametogony</kwd>
        <kwd>sporogony</kwd>
        <kwd>macrogamete</kwd>
        <kwd>microgamete</kwd>
        <kwd>flotation method</kwd>
        <kwd>Fülleborn method</kwd>
      </kwd-group>
      <kwd-group xml:lang="ru">
        <kwd>эймериоз</kwd>
        <kwd>кролик</kwd>
        <kwd>ооциста</kwd>
        <kwd>простейшие</kwd>
        <kwd>шизогония</kwd>
        <kwd>гаметогония</kwd>
        <kwd>спорогония</kwd>
        <kwd>макрогамета</kwd>
        <kwd>микрогамета</kwd>
        <kwd>метод флотации</kwd>
        <kwd>метод Фюллеборна</kwd>
      </kwd-group>
      <kwd-group xml:lang="uz">
        <kwd>eymerioz</kwd>
        <kwd>quyon</kwd>
        <kwd>oosista</kwd>
        <kwd>protozoa</kwd>
        <kwd>shizogoniya</kwd>
        <kwd>gametogoniya</kwd>
        <kwd>sporogoniya</kwd>
        <kwd>makrogameta</kwd>
        <kwd>mikrogameta</kwd>
        <kwd>flotatsiya usuli</kwd>
        <kwd>Fyulleborn usuli</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <back>
    <ref-list>
      <ref id="r1">
        <label>1</label>
        <mixed-citation>Augustine P., Danforth H.D., McAndrew S.J. Monoclonal antibodies reveal antigenic differences in retractile bodies in avian Eimeria sporozoites. Journal of Parasitology, 1988, vol. 74, no. 4, pp. 653–659. <pub-id pub-id-type="doi">10.2307/3282185</pub-id></mixed-citation>
      </ref>
      <ref id="r2">
        <label>2</label>
        <mixed-citation>Akhmadaliyev N.T., Khushnazarov A.Kh., Davlatov R.B. Farg‘ona viloyatining ayrim tumanlarida quyon eymeriozining diagnostikasi va epizootik holati [Diagnostics and epizootic status of rabbit eimeriosis in certain districts of Fergana region]. Ta’lim, fan va innovatsion g‘oyalar dunyoda, 2024, vol. 44, no. 3, pp. 23–29. (in Uzbek)</mixed-citation>
      </ref>
      <ref id="r3">
        <label>3</label>
        <mixed-citation>Akhmadaliyev N.T., Khushnazarov A.Kh., Davlatov R.B. Diagnostics and epizootic status of rabbit eimeriosis in certain districts of Fergana region. Western European Journal of Modern Experiments and Scientific Methods, 2024, vol. 2, no. 4, pp. 56–62.</mixed-citation>
      </ref>
      <ref id="r4">
        <label>4</label>
        <mixed-citation>Bach M., Bach J. International Journal of Immunopharmacology, 1983, no. 3, pp. 274–296.</mixed-citation>
      </ref>
      <ref id="r5">
        <label>5</label>
        <mixed-citation>Davlatov R.B., Khushnazarov A.K. Diagnosis and chemoprophylaxis of rabbit eimeriosis. E3S Web of Conferences, EDP Sciences, 2024, vol. 480, art. 03020. <pub-id pub-id-type="doi">10.1051/e3sconf/202448003020</pub-id></mixed-citation>
      </ref>
      <ref id="r6">
        <label>6</label>
        <mixed-citation>Danforth H.D. Use of monoclonal antibodies directed against Eimeria tenella sporozoites to determine stage specificity and in vitro effect on parasite penetration and development. American Journal of Veterinary Research, 1983, vol. 44, no. 9, p. 44. <pub-id pub-id-type="doi">10.2460/ajvr.1983.44.09.1722</pub-id></mixed-citation>
      </ref>
      <ref id="r7">
        <label>7</label>
        <mixed-citation>Drouet-Viard F. 6th World Rabbit Congress, Toulouse, 1996, pp. 15–19.</mixed-citation>
      </ref>
      <ref id="r8">
        <label>8</label>
        <mixed-citation>Gringoli G., Quessada A., Coppola C. Diffusione dei coccidi negli allevamenti cunicoli campani. Proceedings of the Zoological Society of Calcutta, 1987, p. 16.</mixed-citation>
      </ref>
      <ref id="r9">
        <label>9</label>
        <mixed-citation>Huang Luyi, Chen Hua. Inhibitory effect of chemicals on the development of rabbit coccidial oocysts. Journal of Fujian Agricultural College, 1990, no. 19, pp. 71–76.</mixed-citation>
      </ref>
      <ref id="r10">
        <label>10</label>
        <mixed-citation>John N.V., Zea M.E.R., Kawano T., Omata Y., Saito A., Toyda Y., Mikami T. Identification of carbohydrates on Eimeria stiedae sporozoites and their role in the invasion of cultured cells in vitro. Veterinary Parasitology, 1999, vol. 81, no. 2, pp. 99–105. <pub-id pub-id-type="doi">10.1016/s0304-4017(98)00239-8</pub-id></mixed-citation>
      </ref>
      <ref id="r11">
        <label>11</label>
        <mixed-citation>Katiyar S.K., Gordon V.R., McLaughlin G.L., Edlind T.D. Antiprotozoal activities of benzimidazoles and correlations with beta-tubulin sequence. Antimicrobial Agents and Chemotherapy, 1994, vol. 38, no. 9, pp. 2086–2090. <pub-id pub-id-type="doi">10.1128/aac.38.9.2086</pub-id></mixed-citation>
      </ref>
      <ref id="r12">
        <label>12</label>
        <mixed-citation>Khushnazarov A., Davlatov R. Quyon eymeriozini davolashda yangi eymeriostatikning samaradorligi [Efficacy of a new eimeriostatic in the treatment of rabbit eimeriosis]. Library, 2022, vol. 22, no. 1, pp. 28–29. (in Uzbek)</mixed-citation>
      </ref>
      <ref id="r13">
        <label>13</label>
        <mixed-citation>Khushnazarov A., Davlatov R., Khujakhonov S. Diagnostics and seasonal dynamics of eimeriosis in rabbit breeds kept in Uzbekistan. BIO Web of Conferences, EDP Sciences, 2026, vol. 238, art. 01007. <pub-id pub-id-type="doi">10.1051/bioconf/202623801007</pub-id></mixed-citation>
      </ref>
      <ref id="r14">
        <label>14</label>
        <mixed-citation>Kintzel P., Hasslinger M.-A. Wirksamkeit und Verträglichkeit von Robenidine und Diclazuril bei der Bekämpfung der Kokzidien des Kaninchens. Praktischer Tierarzt, 1995, vol. 76, no. 3, pp. 250–256.</mixed-citation>
      </ref>
      <ref id="r15">
        <label>15</label>
        <mixed-citation>Lajac A.M. The role of gastrointestinal immunity in parasitic infections of small animals. Seminars in Veterinary Medicine and Surgery (Small Animal), 1987, no. 2, p. 4.</mixed-citation>
      </ref>
      <ref id="r16">
        <label>16</label>
        <mixed-citation>Meshkov S.N. Prouchvane na koktsidiozata pri domashnite zaytsi [Study of coccidiosis in domestic rabbits]. Veterinarna Sbirka, 1982, vol. 80, no. 1, pp. 24–25. (in Bulgarian)</mixed-citation>
      </ref>
      <ref id="r17">
        <label>17</label>
        <mixed-citation>Nayak D.C., Rai P. Serum protein profiles in experimental coccidiosis in chicken. Journal of the Indian Veterinary Association, 1986, no. 2, p. 63.</mixed-citation>
      </ref>
      <ref id="r18">
        <label>18</label>
        <mixed-citation>Niedzwiadek S. Kokcydioza a zagospodarowania nawozu kroliczego. Hodowca Drobnego Inwentarza, 1989, no. 37(7/8), pp. 17–18. (in Polish)</mixed-citation>
      </ref>
      <ref id="r19">
        <label>19</label>
        <mixed-citation>Ramisz A. Profilaktyka i zwalczanie kokcydiozy u zwierząt. Wiadomości Parazytologiczne, 1989, no. 34, pp. 551–555. (in Polish)</mixed-citation>
      </ref>
      <ref id="r20">
        <label>20</label>
        <mixed-citation>Rose M.E. Immunity to Eimeria infections. Veterinary Immunology and Immunopathology, 1987, no. 17, pp. 333–343. <pub-id pub-id-type="doi">10.1016/0165-2427(87)90152-8</pub-id></mixed-citation>
      </ref>
      <ref id="r21">
        <label>21</label>
        <mixed-citation>Sambeth W.H. Salinomycin for prevention of coccidiosis in rabbits. Proceedings of the 2nd World Rabbit Congress, Barcelona, 1980, vol. 2, pp. 293–296.</mixed-citation>
      </ref>
      <ref id="r22">
        <label>22</label>
        <mixed-citation>Tsunoda K. Eimeria matsubayashii sp. nov., a new species of rabbit coccidium. Experimental Reports of the Government Experimental Animal Hygiene Station, Tokyo, 1952, p. 25.</mixed-citation>
      </ref>
      <ref id="r23">
        <label>23</label>
        <mixed-citation>Wisher M.H. Identification of the sporozoite antigens of Eimeria tenella. Molecular and Biochemical Parasitology, 1986, vol. 21, no. 1, pp. 7–15. <pub-id pub-id-type="doi">10.1016/0166-6851(86)90073-3</pub-id></mixed-citation>
      </ref>
      <ref id="r24">
        <label>24</label>
        <mixed-citation>Khushnazarov A., Davlatov R. Epizootologiya eymeriy krolikov, lechenie i mery profilaktiki [Epizootiology of rabbit Eimeria, treatment and preventive measures]. Library, 2024, vol. 1, no. 1, pp. 181–184. (in Russian)</mixed-citation>
      </ref>
      <ref id="r25">
        <label>25</label>
        <mixed-citation>Khushnazarov A. Istoriya i sistematicheskoe sostoyanie izucheniya eymerioza krolikov (obzor literatury) [History and systematic status of the study of rabbit eimeriosis (a review)]. Library, 2023, vol. 1, no. 2, pp. 16–19. (in Russian)</mixed-citation>
      </ref>
      <ref id="r26">
        <label>26</label>
        <mixed-citation>Khushnazarov A., Akhmadaliev N., Davlatov R. Epizootologiya eymerioza krolikov [Epizootiology of rabbit eimeriosis]. Library, 2023, vol. 1, no. 2, pp. 94–99. (in Russian)</mixed-citation>
      </ref>
      <ref id="r27">
        <label>27</label>
        <mixed-citation>Khushnazarov A.Kh., Djurayev O.A. Quyonlar eymeriozining patologoanatomik tekshirilishi [Pathoanatomical examination of rabbit eimeriosis]. Yangi O‘zbekiston ustozlari, 2024, vol. 2, no. 29, pp. 294–301. (in Uzbek)</mixed-citation>
      </ref>
    </ref-list>
  </back>
</article>
