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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">research-focus</journal-id>
      <journal-title-group>
        <journal-title>Research Focus International Scientific Journal</journal-title>
        <abbrev-journal-title abbrev-type="publisher">Research Focus</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="epub" publication-format="electronic">2181-3833</issn>
      <publisher>
        <publisher-name>Ilm-fan va innovatsiyalar akademiyasi</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.66073/researchfocus.v5i3.2361</article-id>
      <article-id pub-id-type="other" assigning-authority="relibrary.uz">REL-A-013488</article-id>
      <article-categories>
        <subj-group subj-group-type="oak">
          <subject>14.00.00</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title xml:lang="uz">BIR YOSHGACHA BO‘LGAN BOLALARDA MIOKARDNING PATOMORFOLOGIK O‘ZGARISHLARI</article-title>
        <trans-title-group xml:lang="en">
          <trans-title>PATHOMORPHOLOGICAL ALTERATIONS OF THE MYOCARDIUM IN INFANTS DURING THE FIRST YEAR OF LIFE</trans-title>
        </trans-title-group>
        <trans-title-group xml:lang="ru">
          <trans-title>ПАТОМОРФОЛОГИЧЕСКИЕ ИЗМЕНЕНИЯ МИОКАРДА У ДЕТЕЙ ПЕРВОГО ГОДА ЖИЗНИ</trans-title>
        </trans-title-group>
      </title-group>
      <contrib-group content-type="author">
        <contrib contrib-type="author">
          <name>
            <surname>M.A</surname>
            <given-names>Urunova</given-names>
          </name>
          <aff>v.v.b. dotsent ZARMED universiteti; Assistant ZARMED universiteti</aff>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>M.E</surname>
            <given-names>Ernazarov</given-names>
          </name>
          <aff>v.v.b. dotsent ZARMED universiteti; Assistant ZARMED universiteti</aff>
        </contrib>
      </contrib-group>
      <pub-date publication-format="electronic" date-type="pub" iso-8601-date="2026-04-05">
        <day>05</day>
        <month>04</month>
        <year>2026</year>
      </pub-date>
      <pub-date date-type="collection">
        <year>2026</year>
      </pub-date>
      <volume>5</volume>
      <issue>3</issue>
      <fpage>145</fpage>
      <lpage>151</lpage>
      <permissions>
        <license xlink:href="https://creativecommons.org/licenses/by/4.0">
          <ali:license_ref>https://creativecommons.org/licenses/by/4.0</ali:license_ref>
          <license-p>Ushbu asar Creative Commons Attribution 4.0 International litsenziyasi asosida litsenziyalangan.</license-p>
        </license>
      </permissions>
      <self-uri xlink:href="https://relibrary.uz/REL-A-013488/"/>
      <abstract xml:lang="uz">
        <p>Ushbu maqolada bir yoshgacha bo‘lgan bolalarda miokardning patomorfologik o‘zgarishlari zamonaviy ilmiy adabiyotlar asosida tahlil qilindi. Mavjud tadqiqotlar ko‘rsatishicha, erta ontogenez davrida yurak mushagi gipoksiya, yallig‘lanish va gemodinamik buzilishlarga yuqori sezuvchan bo‘ladi. Adabiyotlar sharhi natijasida perinatal gipoksiya va infeksion omillar ta‘sirida kardiomiyotsitlar gipertrofiyasi, interstitsial shish degenerativ-distrofik jarayonlar hamda boshlang‘ich fibroz o‘zgarishlar rivojlanishi qayd etilishi aniqlandi. Tahlillar miokarddagi strukturaviy qayta qurilishlar mikrosirkulyatsiya buzilishi va hujayraviy gipoksiya bilan chambarchas bog‘liqligini ko‘rsatadi. Ushbu ma‘lumotlar erta tashxis va profilaktik kuzatuvni takomillashtirish zarurligini asoslaydi.</p>
      </abstract>
      <trans-abstract xml:lang="en">
        <p>This article analyzes pathomorphological changes of the myocardium in infants during the first year of life based on contemporary scientific literature. Published data indicate that during early ontogenesis the myocardium demonstrates increased sensitivity to hypoxia inflammatory processes, and hemodynamic disturbances. The literature review reveals that perinatal hypoxia and infectious factors contribute to cardiomyocyte gipertrofiya, interstitial edema, degenerative-dystrophic processes, and early fibrotic alterations. Structural remodeling of the myocardium is shown to be closely associated with microcirculatory impairment and cellular hypoxia. These findings substantiate the need for improving early diagnosis and preventive monitoring strategies.</p>
      </trans-abstract>
      <trans-abstract xml:lang="ru">
        <p>В данной статье проведён анализ патоморфологических изменений миокарда у детей первого года жизни на основе современных научных источников. Согласно опубликованным данным, в период раннего онтогенеза миокард характеризуется повышенной чувствительностью к гипоксии, воспалительным процессам и гемодинамическим нарушениям. Обзор литературы показал, что под воздействием перинатальной гипоксии и инфекционных факторов развиваются гипертрофия кардиомиоцитов, интерстициальный отёк, дегенеративно-дистрофические процессы и начальные фиброзные изменения. Установлено, что структурная перестройка миокарда тесно связана с нарушениями микроциркуляции и клеточной гипоксией. Полученные данные обосновывают необходимость совершенствования ранней диагностики и профилактического мониторинга.</p>
      </trans-abstract>
      <kwd-group xml:lang="uz">
        <kwd>miokard</kwd>
        <kwd>patomorfologik o‘zgarishlar</kwd>
        <kwd>kardiomiyotsit</kwd>
        <kwd>perinatal gipoksiya interstitsial shish</kwd>
        <kwd>fibroz</kwd>
        <kwd>neonatal kardiopatologiya</kwd>
      </kwd-group>
      <kwd-group xml:lang="en">
        <kwd>myocardium</kwd>
        <kwd>pathomorphological changes</kwd>
        <kwd>cardiomyocyte</kwd>
        <kwd>perinatal hypoxia interstitial edema</kwd>
        <kwd>fibrosis</kwd>
        <kwd>neonatal cardiopathology</kwd>
      </kwd-group>
      <kwd-group xml:lang="ru">
        <kwd>миокард</kwd>
        <kwd>патоморфологические изменения</kwd>
        <kwd>кардиомиоцит перинатальная гипоксия</kwd>
        <kwd>интерстициальный отёк</kwd>
        <kwd>фиброз</kwd>
        <kwd>неонатальная кардиопатология</kwd>
      </kwd-group>
    </article-meta>
  </front>
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</article>
