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<article xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.3" xml:lang="uz">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">research-focus</journal-id>
      <journal-title-group>
        <journal-title>Research Focus International Scientific Journal</journal-title>
        <abbrev-journal-title abbrev-type="publisher">Research Focus</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="epub" publication-format="electronic">2181-3833</issn>
      <publisher>
        <publisher-name>Ilm-fan va innovatsiyalar akademiyasi</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.66073/researchfocus.v5i4.2329</article-id>
      <article-id pub-id-type="other" assigning-authority="relibrary.uz">REL-A-013456</article-id>
      <article-categories>
        <subj-group subj-group-type="oak">
          <subject>16.00.00</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title xml:lang="uz">QO‘YLAR KLOSTRIDIOZLARIGA QARSHI VAKSINANI IMMUNOSTIMULYATOR VA VITAMIN BILAN BIRGA QO‘LLAGANDA QO‘YLAR QONIDAGI GEMATOLOGIK VA BIOKIMYOVIY O‘ZGARISHLAR NATIJALARI</article-title>
        <trans-title-group xml:lang="en">
          <trans-title>HEMATOLOGICAL AND BIOCHEMICAL CHANGES IN SHEEP BLOOD FOLLOWING THE COMBINED ADMINISTRATION OF A VACCINE AGAINST CLOSTRIDIAL INFECTIONS WITH IMMUNOSTIMULANTS AND VITAMINS</trans-title>
        </trans-title-group>
        <trans-title-group xml:lang="ru">
          <trans-title>ГЕМАТОЛОГИЧЕСКИЕ И БИОХИМИЧЕСКИЕ ИЗМЕНЕНИЯ В КРОВИ ОВЕЦ ПРИ СОВМЕСТНОМ ПРИМЕНЕНИИ ВАКЦИНЫ ПРОТИВ КЛОСТРИДИОЗОВ С ИММУНОСТИМУЛЯТОРАМИ И ВИТАМИНАМИ</trans-title>
        </trans-title-group>
      </title-group>
      <contrib-group content-type="author">
        <contrib contrib-type="author">
          <name>
            <surname>Ergashev</surname>
            <given-names>N.B.</given-names>
          </name>
          <aff>Samarqand davlat veterinariya meditsinasi, chorvachilik va biotexnologiyalar universiteti; Toshkent filiali; Toshkent davlat agrar universiteti</aff>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Mengliyev</surname>
            <given-names>G‘.A.</given-names>
          </name>
          <aff>Samarqand davlat veterinariya meditsinasi, chorvachilik va biotexnologiyalar universiteti; Toshkent filiali; Toshkent davlat agrar universiteti</aff>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Salimov</surname>
            <given-names>I.X.</given-names>
          </name>
          <aff>Samarqand davlat veterinariya meditsinasi, chorvachilik va biotexnologiyalar universiteti; Toshkent filiali; Toshkent davlat agrar universiteti</aff>
        </contrib>
      </contrib-group>
      <pub-date publication-format="electronic" date-type="pub" iso-8601-date="2026-05-05">
        <day>05</day>
        <month>05</month>
        <year>2026</year>
      </pub-date>
      <pub-date date-type="collection">
        <year>2026</year>
      </pub-date>
      <volume>5</volume>
      <issue>4</issue>
      <fpage>220</fpage>
      <lpage>224</lpage>
      <permissions>
        <license xlink:href="https://creativecommons.org/licenses/by/4.0">
          <ali:license_ref>https://creativecommons.org/licenses/by/4.0</ali:license_ref>
          <license-p>Ushbu asar Creative Commons Attribution 4.0 International litsenziyasi asosida litsenziyalangan.</license-p>
        </license>
      </permissions>
      <self-uri xlink:href="https://relibrary.uz/REL-A-013456/"/>
      <abstract xml:lang="uz">
        <p>Tadqiqotda qo‘ylarni klostridioz kasalliklariga qarshi emlash jarayonida organizmning tabiiy rezistentligini oshirish maqsadida E-Selen va Gamavit veterinariya preparatlari qo‘llanildi. Tajriba hayvonlaridan qon namunalari emlash va preparatlarni yuborishdan oldin, shuningdek, ularni qo‘llagandan keyin 14-, 35- va 180-kunlarda olindi. Qon namunalarida eritrotsitlar, leykotsitlar, gemoglobin miqdori hamda eritrotsitlarning cho‘kish tezligi (EChT), shuningdek, qon zardobining biokimyoviy ko‘rsatkichlari aniqlandi. Tadqiqot natijalari qo‘ylar qonida eritrotsitlar, leykotsitlar va gemoglobin konsentratsiyasining ishonchli darajada, shuningdek, qon zardobining biokimyoviy ko‘rsatkichlari oshganligini ko‘rsatdi.</p>
      </abstract>
      <trans-abstract xml:lang="en">
        <p>In this study, the veterinary preparations E-Selenium and Gamavit were administered to sheep during vaccination against clostridial diseases in order to enhance the natural resistance of the organism. Blood samples were collected from experimental animals prior to vaccination and administration of the preparations, as well as on days 14, 35, and 180 after treatment. The blood samples were analyzed for erythrocyte count, leukocyte count, hemoglobin concentration, erythrocyte sedimentation rate (ESR), and biochemical parameters of blood serum. The results of the study demonstrated a statistically significant increase in erythrocytes leukocytes, and hemoglobin concentration in the blood of sheep, as well as an elevation in biochemical parameters of blood serum.</p>
      </trans-abstract>
      <trans-abstract xml:lang="ru">
        <p>В данном исследовании с целью повышения естественной резистентности организма овец при вакцинации против клостридиозных заболеваний применялись ветеринарные препараты E-Selenium и Гамавит. Образцы крови у подопытных животных отбирались до вакцинации и введения препаратов, а также на 14-е, 35-е и 180-е сутки после их применения. В образцах крови определяли количество эритроцитов и лейкоцитов, концентрацию гемоглобина, скорость оседания эритроцитов (СОЭ), а также биохимические показатели сыворотки крови. Результаты исследования показали статистически достоверное увеличение количества эритроцитов, лейкоцитов и концентрации гемоглобина, а также улучшение биохимических показателей сыворотки крови у овец.</p>
      </trans-abstract>
      <kwd-group xml:lang="uz">
        <kwd>Qo‘y</kwd>
        <kwd>qon</kwd>
        <kwd>E-Selen</kwd>
        <kwd>Gamavit</kwd>
        <kwd>vaksina</kwd>
        <kwd>gemoglobin</kwd>
        <kwd>eritrotsitlar</kwd>
        <kwd>leykotsitlar globulinlar</kwd>
        <kwd>albuminlar</kwd>
      </kwd-group>
      <kwd-group xml:lang="en">
        <kwd>sheep</kwd>
        <kwd>blood</kwd>
        <kwd>E-Selenium</kwd>
        <kwd>Gamavit</kwd>
        <kwd>vaccine</kwd>
        <kwd>hemoglobin</kwd>
        <kwd>erythrocytes leukocytes</kwd>
        <kwd>globulins</kwd>
        <kwd>albumins</kwd>
      </kwd-group>
      <kwd-group xml:lang="ru">
        <kwd>овцы</kwd>
        <kwd>кровь</kwd>
        <kwd>E-Selenium</kwd>
        <kwd>Гамавит</kwd>
        <kwd>вакцина</kwd>
        <kwd>гемоглобин эритроциты</kwd>
        <kwd>лейкоциты</kwd>
        <kwd>глобулины</kwd>
        <kwd>альбумины</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <back>
    <ref-list>
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        <label>1</label>
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    </ref-list>
  </back>
</article>
