research-focus Research Focus International Scientific Journal Research Focus 2181-3833 Ilm-fan va innovatsiyalar akademiyasi 10.66073/researchfocus.v5i5.2273 REL-A-013403 14.00.00 VITAMIN D LEVEL AND ITS RELATIONSHIP WITH CYTOKINE LEVEL IN BRONCHO-OBSTRUCTIVE SYNDROME IN CHILDREN УРОВЕНЬ ВИТАМИНА D И ЕГО СВЯЗЬ С УРОВНЕМ ЦИТОКИНОВ ПРИ БРОНХООБСТРУКТИВНОМ СИНДРОМЕ У ДЕТЕЙ BOLALARDA BRONXOOBSTRUKTIV SINDROMDA VITAMIN D DARAJASI VA UNING SITOKINLAR DARAJASI BILAN BOG‘LIQLIGI Omonovna Turayeva Nafisa Ph.D., Associate Professor, Samarkand State Medical University (Samarkand, Uzbekistan) Azizovna Khamzaeva Kamina Ph.D., Associate Professor, Samarkand State Medical University (Samarkand, Uzbekistan) 05 06 2026 2026 5 5 194 200 https://creativecommons.org/licenses/by/4.0 This work is licensed under a Creative Commons Attribution 4.0 International License.

The aim of the study was to investigate the effect of vitamin D on the course of broncho-obstructive syndrome in children and to determine its relationship with cytokine status. The study involved 86 patients aged 3 to 15 years with acute obstructive bronchitis, recurrent obstructive bronchitis and bronchial asthma. The patients underwent a single set of diagnostic studies: clinical examination, immunological examination, and a study of vitamin D levels in blood serum. The results of the study showed that vitamin D deficiency was accompanied by the development of secondary immune deficiency.

Цель исследования — изучить влияние витамина D на течение бронхообструктивного синдрома у детей и определить его связь с цитокиновым статусом. В исследовании приняли участие 86 пациентов в возрасте от 3 до 15 лет с острым обструктивным бронхитом, рецидивирующим обструктивным бронхитом и бронхиальной астмой. Пациентам был проведён единый комплекс диагностических исследований: клинический осмотр, иммунологическое обследование и исследование уровня витамина D в сыворотке крови. Результаты исследования показали, что дефицит витамина D сопровождался развитием вторичного иммунодефицита.

Tadqiqotning maqsadi bolalardagi bronxoobstruktiv sindromning kechishiga vitamin D ning ta‘sirini o‘rganish va uning sitokin statusi bilan o‘zaro bog‘liqligini aniqlashdan iborat edi. Tadqiqotda o‘tkir obstruktiv bronxit, retsidivlanuvchi obstruktiv bronxit va bronxial astma bilan og‘rigan 3 yoshdan 15 yoshgacha bo‘lgan 86 nafar bemor ishtirok etdi. Bemorlarga yagona diagnostik tekshiruvlar majmuasi: klinik tekshiruv, immunologik tekshiruv va qon zardobida vitamin D darajasini aniqlash o‘tkazildi. Tadqiqot natijalari vitamin D yetishmovchiligi ikkilamchi immun yetishmovchiligi rivojlanishi bilan birga kelishini ko‘rsatdi.

 broncho-obstructive syndrome vitamin D immune status children бронхообструктивный синдром витамин D иммунный статус дети bronxoobstruktiv sindrom vitamin D immun status bolalar Belykh N. A. Modern approaches to diagnostics and therapy of broncho-obstructive syndrome of infectious genesis in children / N. A. Belykh, L. A. Zalivnaya // Actual Infectology. — 2015. — Vol. 6, No. 1. — P. 88–93. Yulish E. I. On risk factors for the development of broncho-obstructive syndrome in young children / E. I. Yulish, Yu. A. Soroka, O. E. Chernysheva // Child Health. — 2012. — Vol. 41, No. 6. — P. 85–88. Gromova O. A., Torshin I. Yu. Vitamin D — a paradigm shift. — M.: GEOTAR-Media, 2017. — 568 p. ISBN: 978-5-9704-4058-2. Schrumpf J. A., Amatngalim G. D., Veldkamp J. B., Verhoosel R. M., Ninaber D. K., Ordonez S. R., van der Does A. M., Haagsman H. P., Hiemstra P. S. Proinflammatory cytokines impair vitamin D-induced host defense in cultured airway epithelial cells // Am. J. Respir. Cell Mol. Biol. — 2017, Feb 23. DOI: 10.1165/rcmb.2016-0289OC. Aryan Z., Rezaei N., Camargo C. A. Jr. Vitamin D status, aeroallergen sensitization, and allergic rhinitis: a systematic review and meta-analysis // Int. Rev. Immunol. — 2017. — Vol. 36, No. 1. — P. 41–53. DOI: 10.1080/08830185.2016.1272600. Sundaram M. E., Coleman L. A. Vitamin D and influenza // Adv. Nutr. — 2012. — Vol. 3, No. — P. 517–525. DOI: 10.3945/an.112.002162. Lang P. O., Samaras D. Aging adults and seasonal influenza: does the vitamin D status (h)arm the body? // J. Aging Res. — 2012. — Vol. 2012. — Art. 806198. Stagi S., Bertini F. Vitamin D levels and effects of vitamin D replacement in children with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome // Int. J. Pediatr. Otorhinolaryngol. — 2014. — Vol. 78, No. 6. — P. 964–968. Amaya-Mejia A. S., O’Farrill-Romanillos P. M., Galindo-Pacheco L. V., Vargas-Ortega G., Mendoza-Zubieta V., Del Rivero-Hernandez L. G., Segura-Mendez N. H. Vitamin D deficiency in patients with common variable immunodeficiency, with autoimmune diseases and bronchiectasis // Rev. Alerg. Mex. — 2013. — Vol. 60, No. 3. — P. 110–116. Zakharova I. N., Klimov L. Ya., Kasyanova A. N., et al. The role of antimicrobial peptides and vitamin D in the formation of anti-infective defense // Pediatrics named after G. N. Speransky. — 2017. — Vol. 96, No. 4. — P. 171–179. Riverin B. D., Maguire J. L., Li P. Vitamin D supplementation for childhood asthma: a systematic review and meta-analysis // PLoS One. — 2015. — Vol. 10, No. 8. — Art. e0136841. Man L., Zhang Z., Zhang M., Zhang Y., Li J., Zheng N., Cao Y., Chi M., Chao Y., Huang Q., Song C., Xu B. Association between vitamin D deficiency and insufficiency and the risk of childhood asthma: evidence from a meta-analysis // Int. J. Clin. Exp. Med. — 2015. — Vol. 8, No. 4. — P. 5699–5706. Feng H., Xun P., Pike K., Wills A. K., Chawes B. L., Bisgaard H., Cai W., Wan Y., He K. In utero exposure to 25-hydroxyvitamin D and risk of childhood asthma, wheeze, and respiratory tract infections: a meta-analysis of birth cohort studies // J. Allergy Clin. Immunol. — 2016. — S0091-6749(16)30960. Neme A., Nurminen V., Seuter S., Carlberg C. The vitamin D-dependent transcriptome of human monocytes // J. Steroid Biochem. Mol. Biol. — 2016, Nov. — Vol. 164. — P. 180–187. DOI: 10.1016/j.jsbmb.2015.10.018. Zakharova I. N., Maltsev S. V., Borovik T. E., Yatsyk G. V., Malyavskaya S. I., Vakhlova I. V., Shumatova T. A., Romantsova E. B., Romanyuk F. P., Klimov L. Ya., Elkina T. N., Pirozhkova N. I., Kolesnikova S. M., Kuryaninova V. A., Vasilyeva S. V., Mozzhukhina M. V., Evseeva E. A. Vitamin D deficiency in young children in Russia (results of a multicenter study — winter 2013–2014) // Questions of Pharmacoepidemiology. — 2014. — P. 75–80. Jat K. R. Vitamin D deficiency and lower respiratory tract infections in children: a systematic review and meta-analysis of observational studies // Trop. Doct. — 2017, Jan. — Vol. 47, No.