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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">research-focus</journal-id>
      <journal-title-group>
        <journal-title>Research Focus International Scientific Journal</journal-title>
        <abbrev-journal-title abbrev-type="publisher">Research Focus</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="epub" publication-format="electronic">2181-3833</issn>
      <publisher>
        <publisher-name>Ilm-fan va innovatsiyalar akademiyasi</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.66073/researchfocus.v5i2.2078</article-id>
      <article-id pub-id-type="other" assigning-authority="relibrary.uz">REL-A-013365</article-id>
      <article-categories>
        <subj-group subj-group-type="oak">
          <subject>16.00.00</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title xml:lang="en">PHARMACOLOGY AND CHEMOTHERAPEUTIC EFFECT OF PENSTREP 400 ON CATTLE</article-title>
        <trans-title-group xml:lang="ru">
          <trans-title>ФАРМАКОЛОГИЯ И ХИМИОТЕРАПЕВТИЧЕСКОЕ ДЕЙСТВИЕ ПЕНСТРЕП 400 НА КРУПНЫЙ РОГАТЫЙ СКОТ</trans-title>
        </trans-title-group>
        <trans-title-group xml:lang="uz">
          <trans-title>PENSTREP 400 PREPARATINING FARMAKOLOGIYASI VA QORAMOLLARGA KIMIOTERAPEVTIK TASIRI</trans-title>
        </trans-title-group>
      </title-group>
      <contrib-group content-type="author">
        <contrib contrib-type="author">
          <string-name>Rejepbayev J.E.</string-name>
          <aff>Nukus branch of the Samarkand State University of Veterinary Medicine, Animal Husbandry and Biotechnologies</aff>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Gabbarova U.U.</string-name>
          <aff>Tashkent branch of the Samarkand State University of Veterinary Medicine, Animal Husbandry and Biotechnologies</aff>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Zoitova S.A.</string-name>
        </contrib>
      </contrib-group>
      <pub-date publication-format="electronic" date-type="pub" iso-8601-date="2026-03-05">
        <day>05</day>
        <month>03</month>
        <year>2026</year>
      </pub-date>
      <pub-date date-type="collection">
        <year>2026</year>
      </pub-date>
      <volume>5</volume>
      <issue>2</issue>
      <fpage>300</fpage>
      <lpage>303</lpage>
      <permissions>
        <license xlink:href="https://creativecommons.org/licenses/by/4.0">
          <ali:license_ref>https://creativecommons.org/licenses/by/4.0</ali:license_ref>
          <license-p>This work is licensed under a Creative Commons Attribution 4.0 International License.</license-p>
        </license>
      </permissions>
      <self-uri xlink:href="https://relibrary.uz/REL-A-013365/"/>
      <abstract xml:lang="en">
        <p>This article describes the pharmacological properties of Penstrep 400 and its chemotherapeutic effect in the treatment of infectious diseases in cattle. The combination of penicillin and streptomycin antibiotics, which are part of the preparation, has a wide spectrum of action and exhibits high bactericidal effectiveness against gram-positive and gram-negative microorganisms. The absorption, distribution, and excretion of Penstrep 400 in the body, as well as its ability to maintain therapeutic concentration for a long time, were analyzed. The results of the study showed the effectiveness of the drug in the treatment of infections of the respiratory tract, digestive system, genitourinary organs, and mammary glands.</p>
      </abstract>
      <trans-abstract xml:lang="ru">
        <p>В данной статье освещены фармакологические свойства препарата Пенстреп 400 и его химиотерапевтическое действие при лечении инфекционных заболеваний крупного рогатого скота. Комбинация антибиотиков пенициллина и стрептомицина, входящих в состав препарата, обладает широким спектром действия и проявляет высокую бактерицидную эффективность против грамположительных и грамотрицательных микроорганизмов. Проанализированы особенности всасывания, / распределения и выведения пенстреп 400 в организме, а также его способность поддерживать терапевтическую концентрацию в течение длительного времени. Результаты исследования показали эффективность препарата при лечении инфекций дыхательных путей, пищеварительной системы, мочеполовых органов и молочных желез.</p>
      </trans-abstract>
      <trans-abstract xml:lang="uz">
        <p>Mazkur maqolada Penstrep 400 preparatining farmakologik xususiyatlari hamda qoramollarda infeksion kasalliklarni davolashdagi ximioterapevtik ta‘siri yoritib berilgan. Preparat tarkibiga kiruvchi penitsillin va streptomitsin antibiotiklarining kombinatsiyasi keng ta‘sir doirasiga ega bo‘lib, gram-musbat va gram-manfiy mikroorganizmlarga nisbatan yuqori bakteritsid samaradorlik ko‘rsatadi. Penstrep 400 ning organizmda so‘rilishi, taqsimlanishi va chiqarilishi, shuningdek uning terapevtik konsentratsiyani uzoq muddat saqlab turish xususiyatlari tahlil qilingan. Tadqiqot natijalari preparatning nafas olish yo‘llari, ovqat hazm qilish tizimi, siydik-jinsiy a‘zolar va sut bezlari infeksiyalarini davolashda samarali ekanligini ko‘rsatdi.</p>
      </trans-abstract>
      <kwd-group xml:lang="en">
        <kwd>Penstrep 400</kwd>
        <kwd>penicillin</kwd>
        <kwd>streptomycin</kwd>
        <kwd>combined antibiotic</kwd>
        <kwd>pharmacological properties</kwd>
        <kwd>antimicrobial effect</kwd>
        <kwd>bactericidal effect</kwd>
        <kwd>gram-positive bacteria</kwd>
        <kwd>gram-negative bacteria</kwd>
      </kwd-group>
      <kwd-group xml:lang="ru">
        <kwd>Пенстреп 400</kwd>
        <kwd>пенициллин</kwd>
        <kwd>стрептомицин</kwd>
        <kwd>комбинированный антибиотик</kwd>
        <kwd>фармакологические свойства</kwd>
        <kwd>антимикробный эффект</kwd>
        <kwd>бактерицидное действие</kwd>
        <kwd>грамположительные бактерии</kwd>
        <kwd>грамотрицательные бактерии</kwd>
      </kwd-group>
      <kwd-group xml:lang="uz">
        <kwd>Penstrep 400</kwd>
        <kwd>penitsillin</kwd>
        <kwd>streptomitsin</kwd>
        <kwd>kombinatsiyalangan antibiotik</kwd>
        <kwd>farmakologik xususiyatlar</kwd>
        <kwd>antimikrob ta‘sir</kwd>
        <kwd>bakteritsid ta‘sir</kwd>
        <kwd>gram-musbat bakteriyalar</kwd>
        <kwd>gram- manfiy bakteriyalar</kwd>
      </kwd-group>
    </article-meta>
  </front>
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</article>
