research-focus Research Focus International Scientific Journal Research Focus 2181-3833 Ilm-fan va innovatsiyalar akademiyasi 10.66073/researchfocus.v4i11.1869 REL-A-013185 14.00.00 РОЛЬ КОЖНОГО МИКРОБИОМА В ПАТОГЕНЕЗЕ СТАФИЛОКОККОВЫХ И СТРЕПТОКОККОВЫХ ПИОДЕРМИЙ THE ROLE OF THE SKIN MICROBIOME IN THE PATHOGENESIS OF STAPHYLOCOCCAL AND STREPTOCOCCAL PYODERMA STAFILOKOKK VA STREPTOKOKK PIODERMIYALARI PATOGENEZIDA TERI MIKROBIOMINING ROLI Баротова Мавжуда Раимовна Самаркандский государственный медицинский университет. Узбекистан, г. Самарканд, ул. Амира Темура, 18. 05 12 2025 2025 4 11 294 298 https://creativecommons.org/licenses/by/4.0 Это произведение доступно по лицензии Creative Commons «Attribution» («Атрибуция») 4.0 Всемирная.

в данном исследовании проведён комплексный анализ кожного микробиома у пациентов со стафилококковыми и стрептококковыми пиодермиями с целью оценки его дисбиотических изменений и роли в клиническом течении заболевания. Анализ проводился на основе сравнения с контрольной группой здоровых добровольцев. На основе данных микробиологического и молекулярно-генетического исследования определены степень дисбиоза, уровни колонизации патогенами и наличие генов вирулентности. Выраженность воспаления, частота рецидивов и распространённость поражений были проанализированы с использованием корреляционного анализа. Кроме того, для клинических изолятов определён профиль антибиотикорезистентности, что является важным прогностическим и терапевтическим показателем.

This study presents a comprehensive analysis of the skin microbiome in patients with staphylococcal and streptococcal pyoderma in order to assess its dysbiotic changes and its role in the clinical course of the disease. The analysis was based on a comparison with a control group of healthy volunteers. On the basis of microbiological and molecular genetic data, the degree of dysbiosis, the levels of colonisation by pathogens and the presence of virulence genes were determined. The severity of inflammation, the frequency of relapses and the extent of the lesions were analysed using correlation analysis. In addition, the antibiotic resistance profile of the clinical isolates was determined, which is an important prognostic and therapeutic indicator.

Ushbu tadqiqotda stafilokokk va streptokokk piodermiyalari bilan og‘rigan bemorlarda teri mikrobiomining kompleks tahlili o‘tkazilib, uning disbiotik o‘zgarishlari va kasallikning klinik kechishidagi roli baholandi. Tahlil sog‘lom ko‘ngillilardan iborat nazorat guruhi bilan taqqoslash asosida o‘tkazildi. Mikrobiologik va molekulyar-genetik tadqiqot ma‘lumotlari asosida disbioz darajasi, patogenlar bilan kolonizatsiya darajalari va virulentlik genlarining mavjudligi aniqlandi. Yallig‘lanishning ifodalanganligi, retsidivlar chastotasi va zararlanishlarning tarqalganligi korrelyatsion tahlil yordamida o‘rganildi. Bundan tashqari, klinik izolyatlar uchun antibiotikorezistentlik profili aniqlandi, bu esa muhim prognostik va terapevtik ko‘rsatkichdir.

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