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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">research-focus</journal-id>
      <journal-title-group>
        <journal-title>Research Focus International Scientific Journal</journal-title>
        <abbrev-journal-title abbrev-type="publisher">Research Focus</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="epub" publication-format="electronic">2181-3833</issn>
      <publisher>
        <publisher-name>Ilm-fan va innovatsiyalar akademiyasi</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.66073/researchfocus.v4i11.1861</article-id>
      <article-id pub-id-type="other" assigning-authority="relibrary.uz">REL-A-013177</article-id>
      <article-categories>
        <subj-group subj-group-type="oak">
          <subject>14.00.00</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title xml:lang="en">EARLY CEREBRAL REVASCULARIZATION FOR THE PREVENTION OF RECURRENT ISCHEMIC STROKE</article-title>
        <trans-title-group xml:lang="ru">
          <trans-title>РАННЯЯ ЦЕРЕБРАЛЬНАЯ РЕВАСКУЛЯРИЗАЦИЯ ДЛЯ ПРОФИЛАКТИКИ ПОВТОРНОГО ИШЕМИЧЕСКОГО ИНСУЛЬТА</trans-title>
        </trans-title-group>
        <trans-title-group xml:lang="uz">
          <trans-title>TAKRORIY ISHEMIK INSULT PROFILAKTIKASI UCHUN ERTA SEREBRAL REVASKULYARIZATSIYA</trans-title>
        </trans-title-group>
      </title-group>
      <contrib-group content-type="author">
        <contrib contrib-type="author">
          <string-name>Kilichev Farrukh Akhmadovich</string-name>
          <aff>Samarkand Branch of the Republican Scientific Center of Emergency Medical Care under the Ministry of Health of the Republic of Uzbekistan, Neurosurgery Department</aff>
        </contrib>
      </contrib-group>
      <pub-date publication-format="electronic" date-type="pub" iso-8601-date="2025-12-05">
        <day>05</day>
        <month>12</month>
        <year>2025</year>
      </pub-date>
      <pub-date date-type="collection">
        <year>2025</year>
      </pub-date>
      <volume>4</volume>
      <issue>11</issue>
      <fpage>236</fpage>
      <lpage>243</lpage>
      <permissions>
        <license xlink:href="https://creativecommons.org/licenses/by/4.0">
          <ali:license_ref>https://creativecommons.org/licenses/by/4.0</ali:license_ref>
          <license-p>This work is licensed under a Creative Commons Attribution 4.0 International License.</license-p>
        </license>
      </permissions>
      <self-uri xlink:href="https://relibrary.uz/REL-A-013177/"/>
      <abstract xml:lang="en">
        <p>This study aimed to evaluate the safety and efficacy of early surgical revascularization of the brachiocephalic arteries in patients with acute ischemic stroke. Seven patients underwent carotid endarterectomy or stenting within 7 days of symptom onset. Surgical intervention was performed after stabilization of neurological status at a low NIHSS score. Clinical outcomes, complication rates, and neurological improvement were analyzed and compared with international literature. The results suggest that, with strict patient selection (neurological deficit ≤3 on Rankin and lesion size ≤4 cm), early revascularization may be both safe and associated with improved neurological recovery. Current global data support this strategy for both endarterectomy and stenting. However, broader studies are needed to confirm these findings and develop standardized inclusion criteria.</p>
      </abstract>
      <trans-abstract xml:lang="ru">
        <p>Целью исследования явилось определение безопасности и эффективности ранней хирургической реконструкции брахиоцефальных артерий у пациентов с ишемическим инсультом. В исследование включены 7 пациентов, которым была выполнена каротидная эндартерэктомия или стентирование в течение 7 суток от момента развития инсульта. Хирургическое вмешательство проводилось после достижения неврологического плато при стабильно низких значениях по шкале NIHSS. Проанализированы клинические исходы, частота осложнений, динамика неврологического статуса и сопоставлены данные с результатами мировой литературы. Результаты показали, что при строгом отборе пациентов (по степени неврологического дефицита и объему ишемии) ранняя реваскуляризация может быть безопасной и сопровождается значительным улучшением неврологических показателей. Представлены современные данные из литературы, подтверждающие оправданность подобной тактики, в том числе при стентировании и эндартэрэктомии. Полученные данные требуют подтверждения в крупномасштабных исследованиях.</p>
      </trans-abstract>
      <trans-abstract xml:lang="uz">
        <p>Ushbu tadqiqotda o‘tkir ishemik insultga uchragan bemorlarda brakiosefal arteriyalarni erta jarrohlik yo‘li bilan revascularizatsiya qilishning xavfsizligi va samaradorligi baholandi. Tadqiqotga insult rivojlanganidan keyin 7 kun ichida karotid endarterektomiya yoki stentlash o‘tkazilgan 7 bemor kiritildi. Operatsiyalar nevrologik simptomlar barqarorlashgandan so‘ng, past NIHSS ballari fonida o‘tkazildi. Klinik natijalar, asoratlar chastotasi va nevrologik holatdagi ijobiy dinamikalar tahlil qilindi va xalqaro adabiyotlar bilan taqqoslandi. Tadqiqot natijalari shuni ko‘rsatdiki, nevrologik tanqislik darajasi va infarkt hajmi bo‘yicha qat‘iy tanlov asosida erta revascularizatsiya xavfsiz bo‘lishi va bemorlarning funksional holatini yaxshilashi mumkin. Dunyodagi zamonaviy adabiyotlar bu yondashuvni tasdiqlaydi, ammo keng miqyosdagi qo‘shimcha tadqiqotlar talab etiladi.</p>
      </trans-abstract>
      <kwd-group xml:lang="en">
        <kwd>ischemic stroke</kwd>
        <kwd>carotid endarterectomy</kwd>
        <kwd>stenting</kwd>
        <kwd>brachiocephalic arteries</kwd>
        <kwd>early revascularization</kwd>
        <kwd>neurological deficit</kwd>
      </kwd-group>
      <kwd-group xml:lang="ru">
        <kwd>ишемический инсульт</kwd>
        <kwd>каротидная эндартерэктомия</kwd>
        <kwd>стентирование</kwd>
        <kwd>брахиоцефальные артерии</kwd>
        <kwd>ранняя реваскуляризация</kwd>
        <kwd>неврологический дефицит</kwd>
      </kwd-group>
      <kwd-group xml:lang="uz">
        <kwd>ishemik insult</kwd>
        <kwd>karotid endarterektomiya</kwd>
        <kwd>stentlash</kwd>
        <kwd>brakiosefal arteriyalar</kwd>
        <kwd>erta revascularizatsiya</kwd>
        <kwd>nevrologik tanqislik</kwd>
      </kwd-group>
    </article-meta>
  </front>
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</article>
