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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">research-focus</journal-id>
      <journal-title-group>
        <journal-title>Research Focus International Scientific Journal</journal-title>
        <abbrev-journal-title abbrev-type="publisher">Research Focus</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="epub" publication-format="electronic">2181-3833</issn>
      <publisher>
        <publisher-name>Ilm-fan va innovatsiyalar akademiyasi</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.66073/researchfocus.v4i3.1524</article-id>
      <article-id pub-id-type="other" assigning-authority="relibrary.uz">REL-A-012856</article-id>
      <article-categories>
        <subj-group subj-group-type="oak">
          <subject>14.00.00</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title xml:lang="en">THE CARDIOVASCULAR BENEFITS OF ANTI-OBESITY MEDICATIONS: A GAME-CHANGER IN HEART HEALTH</article-title>
        <trans-title-group xml:lang="ru">
          <trans-title>ПРЕИМУЩЕСТВА ПРЕПАРАТОВ ПРОТИВ ОЖИРЕНИЯ ДЛЯ СЕРДЕЧНО - СОСУДИСТОЙ СИСТЕМЫ: ПЕРЕЛОМНЫЙ МОМЕНТ В ЗДОРОВЬЕ СЕРДЦА</trans-title>
        </trans-title-group>
        <trans-title-group xml:lang="uz">
          <trans-title>SEMIZLIKKA QARSHI DORILARNING YURAK-QON TOMIR TIZIMI UCHUN FOYDALARI: YURAK SALOMATLIGIDA TUB BURILISH</trans-title>
        </trans-title-group>
      </title-group>
      <contrib-group content-type="author">
        <contrib contrib-type="author">
          <string-name>Dr. Imran Aslam</string-name>
          <aff>Ph.D. Research Assistant &amp; Assistant Professor, Department of Pharmacology Samarkand State Medical University</aff>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Dr. Muhammad Kalim Raza</string-name>
          <aff>Assistant professor, Samarkand State Medical University, Samarkand, Uzbekistan</aff>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Dr. Ayesha Ashraf</string-name>
          <aff>Assistant Professor, Department Histology/Cytology/Embryology Samarkand State Medical University</aff>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Dr. Vishal Chauhan</string-name>
          <aff>Assistant Professor, Department Histology/Cytology/Embryology Samarkand State Medical University</aff>
        </contrib>
      </contrib-group>
      <pub-date publication-format="electronic" date-type="pub" iso-8601-date="2025-04-05">
        <day>05</day>
        <month>04</month>
        <year>2025</year>
      </pub-date>
      <pub-date date-type="collection">
        <year>2025</year>
      </pub-date>
      <volume>4</volume>
      <issue>3</issue>
      <fpage>149</fpage>
      <lpage>154</lpage>
      <permissions>
        <license xlink:href="https://creativecommons.org/licenses/by/4.0">
          <ali:license_ref>https://creativecommons.org/licenses/by/4.0</ali:license_ref>
          <license-p>This work is licensed under a Creative Commons Attribution 4.0 International License.</license-p>
        </license>
      </permissions>
      <self-uri xlink:href="https://relibrary.uz/REL-A-012856/"/>
      <abstract xml:lang="en">
        <p>Obesity is a significant global health challenge that increases the chance of developing cardiovascular disorders (CVDs), including heart failure, coronary artery disease, and hypertension. Traditional weight-loss methods often yield limited success, prompting the need for pharmacological interventions. Anti-obesity medications (AOMs) have emerged as effective tools for not only weight reduction but also improving cardiovascular health. This article explores the cardiovascular benefits of AOMs, including their role in lowering blood pressure, improving lipid profiles, reducing inflammation, and enhancing insulin sensitivity. Clinical trials, such as the SELECT and LEADER studies, provide strong evidence that medications like semaglutide, liraglutide, and tirzepatide significantly reduce major cardiovascular events. While AOMs offer promising heart health benefits, they should be integrated into a comprehensive lifestyle approach. This review highlights the transformative impact of anti-obesity medications in reducing cardiovascular risks and improving overall well-being.</p>
      </abstract>
      <trans-abstract xml:lang="ru">
        <p>Ожирение является серьезной глобальной проблемой здравоохранения, которая увеличивает вероятность развития сердечно-сосудистых заболеваний (ССЗ), включая сердечную недостаточность, ишемическую болезнь сердца и гипертонию. Традиционные методы снижения веса часто дают ограниченный успех, что обусловливает необходимость фармакологического вмешательства. Препараты против ожирения (AOM) стали эффективными инструментами не только для снижения веса, но и для улучшения здоровья сердечно-сосудистой системы. В этой статье рассматриваются преимущества AOM для сердечно-сосудистой системы, включая их роль в снижении артериального давления, улучшении липидного профиля, уменьшении воспаления и повышении чувствительности к инсулину. Клинические испытания, такие как исследования SELECT и / LEADER, предоставляют убедительные доказательства того, что такие препараты, как семаглутид, лираглутид и тирзепатид, значительно снижают основные сердечно-сосудистые события. Хотя AOM предлагают многообещающие преимущества для здоровья сердца, их следует интегрировать в комплексный подход к образу жизни. В этом обзоре подчеркивается преобразующее влияние препаратов против ожирения на снижение сердечно-сосудистых рисков и улучшение общего благополучия.</p>
      </trans-abstract>
      <trans-abstract xml:lang="uz">
        <p>Semizlik yurak yetishmovchiligi, yurak koronar arteriyasi kasalligi va gipertoniya kabi yurak-qon tomir kasalliklari (YQTK) rivojlanishi ehtimolini oshiruvchi jiddiy global sog‘liqni saqlash muammosidir. An‘anaviy vazn kamaytirish usullari ko‘pincha cheklangan natija beradi, bu esa farmakologik aralashuvga ehtiyoj tug‘diradi. Semizlikka qarshi dorilar (SQD) nafaqat vaznni kamaytirish, balki yurak-qon tomir salomatligini yaxshilash uchun ham samarali vosita sifatida namoyon bo‘ldi. Ushbu maqolada SQD larning yurak-qon tomir tizimi uchun foydalari, jumladan ularning qon bosimini pasaytirish, lipid profilini yaxshilash, yallig‘lanishni kamaytirish va insulinga sezgirlikni oshirishdagi o‘rni ko‘rib chiqiladi. SELECT va LEADER kabi klinik sinovlar semaglutid, liraglutid va tirzepatid singari dorilar asosiy yurak-qon tomir hodisalarini sezilarli darajada kamaytirishiga kuchli dalil beradi. SQD lar yurak salomatligi uchun umidli foydalar taklif etsa-da, ular turmush tarziga oid kompleks yondashuvga integratsiya qilinishi lozim. Ushbu sharhda semizlikka qarshi dorilarning yurak-qon tomir xavflarini kamaytirish va umumiy farovonlikni yaxshilashdagi tub o‘zgartiruvchi ta‘siri ta‘kidlanadi.</p>
      </trans-abstract>
      <kwd-group xml:lang="en">
        <kwd>Anti-obesity medications</kwd>
        <kwd>cardiovascular health</kwd>
        <kwd>obesity</kwd>
        <kwd>weight loss</kwd>
        <kwd>hypertension</kwd>
        <kwd>lipid profile</kwd>
        <kwd>insulin sensitivity</kwd>
        <kwd>GLP-1 receptor agonists</kwd>
        <kwd>cardiovascular disease prevention</kwd>
        <kwd>metabolic health</kwd>
      </kwd-group>
      <kwd-group xml:lang="ru">
        <kwd>препараты против ожирения</kwd>
        <kwd>здоровье сердечно-сосудистой системы</kwd>
        <kwd>ожирение</kwd>
        <kwd>потеря веса</kwd>
        <kwd>гипертония</kwd>
        <kwd>липидный профиль</kwd>
        <kwd>чувствительность к инсулину</kwd>
        <kwd>агонисты рецепторов GLP-1</kwd>
        <kwd>профилактика сердечно-сосудистых заболеваний</kwd>
        <kwd>метаболическое здоровье</kwd>
      </kwd-group>
      <kwd-group xml:lang="uz">
        <kwd>Semizlikka qarshi dorilar</kwd>
        <kwd>yurak-qon tomir salomatligi</kwd>
        <kwd>semizlik</kwd>
        <kwd>vazn yo‘qotish</kwd>
        <kwd>gipertoniya</kwd>
        <kwd>lipid profili</kwd>
        <kwd>insulinga sezgirlik</kwd>
        <kwd>GLP-1 retseptorlari agonistlari</kwd>
        <kwd>yurak-qon tomir kasalliklari profilaktikasi</kwd>
        <kwd>metabolik salomatlik</kwd>
      </kwd-group>
    </article-meta>
  </front>
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