research-focus Research Focus International Scientific Journal Research Focus 2181-3833 Ilm-fan va innovatsiyalar akademiyasi 10.66073/researchfocus.v2i7.420 REL-A-010696 РЕГЕНЕРАЦИЯ ПЕРЕЛОМОВ ТРУБЧАТЫХ КОСТЕЙ ПРИ САХАРНОМ ДИАБЕТЕ: ИССЛЕДОВАНИЕ И ПЕРСПЕКТИВЫ REGENERATION OF TUBULAR BONE FRACTURES IN DIABETES MELLITUS: RESEARCH AND PROSPECTS QANDLI DIABETDA NAYSIMON SUYAKLAR SINISHINING REGENERATSIYASI: TADQIQOT VA ISTIQBOLLAR Курбонов Хуршед Рахматуллоевич Кафедра гистологии, цитологии и эмбриологии, Самаркандский государственный медицинский университет Курбонов Рахматулло Абдуназарович Самаркандский филиал Республиканского специализированного научно-практического медицинского центра травматологии и ортопедии 05 08 2023 2023 2 7 63 69 https://creativecommons.org/licenses/by/4.0 Это произведение доступно по лицензии Creative Commons «Attribution» («Атрибуция») 4.0 Всемирная.

Цель данной обзорной статьи состоит в исследовании процесса регенерации переломов трубчатых костей у пациентов с сахарным диабетом. В статье рассматриваются особенности заживления переломов в условиях повышенного уровня глюкозы в крови, а также анализируются факторы, влияющие на регенерацию. На основе полученных данных, статья также предлагает перспективы и возможные подходы для улучшения регенерации переломов у пациентов с сахарным диабетом.

The purpose of this review article is to study the process of regeneration of tubular bone fractures in patients with diabetes mellitus. The article examines the features of fracture healing under conditions of elevated blood glucose levels, and also analyses the factors influencing regeneration. On the basis of the data obtained, the article also proposes prospects and possible approaches for improving fracture regeneration in patients with diabetes mellitus.

Ushbu sharh maqolasining maqsadi qandli diabet bilan og‘rigan bemorlarda naysimon suyaklar sinishining regeneratsiya jarayonini o‘rganishdan iborat. Maqolada qondagi glyukoza darajasi oshgan sharoitda suyak sinishining bitish xususiyatlari ko‘rib chiqiladi, shuningdek, regeneratsiyaga ta‘sir qiluvchi omillar tahlil qilinadi. Olingan ma‘lumotlar asosida maqolada qandli diabet bilan og‘rigan bemorlarda suyak sinishi regeneratsiyasini yaxshilash istiqbollari va mumkin bo‘lgan yondashuvlar ham taklif etiladi.

 регенерация костная ткань сахарный диабет трубчатые кости фактор роста костный морфогенетический белок regeneration bone tissue diabetes mellitus tubular bones growth factor bone morphogenetic protein regeneratsiya suyak to‘qimasi qandli diabet naysimon suyaklar o‘sish omili suyak morfogenetik oqsili Berbudi A. et al. Type 2 diabetes and its impact on the immune system //Current diabetes reviews. – 2020. – Т. 16. – №. 5. – С. 442-449. Cabanillas Balsera D. Diabetes mellitus y hábito tabáquico como factores pronósticos del tratamiento endodóntico: revisión sistemática y metaanálisis. – 2021. Cai F. et al. Diabetes mellitus impairs bone regeneration and biomechanics //Journal of Orthopaedic Surgery and Research. – 2023. – Т. 18. – №. 1. – С. 1-10. Camargo W. A. et al. Diabetes mellitus and bone regeneration: a systematic review and meta-analysis of animal studies //Tissue Engineering Part B: Reviews. – 2017. – Т. 23. – №. 5. – С. 471-479. Chen M. et al. PPARβ/δ accelerates bone regeneration in diabetic mellitus by enhancing AMPK/mTOR pathway-mediated autophagy //Stem Cell Research & Therapy. – 2021. – Т. 12. – №. 1. – С. 1-14. Chen W. et al. Fracture risk assessment in diabetes mellitus //Frontiers in endocrinology. – 2022. – Т. 13. – С. 961761. Chen Y. et al. Challenges to improve bone healing under diabetic conditions //Frontiers in Endocrinology. – 2022. – Т. 13. – С. 861878. Compston J. Type 2 diabetes mellitus and bone //Journal of internal medicine. – 2018. – Т. Dai X. et al. Restoration of electrical microenvironment enhances bone regeneration under diabetic conditions by modulating macrophage polarization //Bioactive materials. – 2021. – Т. 6. – №. 7. – С. 2029-2038. Daryabor G. et al. The effects of type 2 diabetes mellitus on organ metabolism and the immune system //Frontiers in immunology. – 2020. – Т. 11. – С. 1582. Davey G. C. et al. Mesenchymal stem cell-based treatment for microvascular and secondary complications of diabetes mellitus //Frontiers in endocrinology. – 2014. – Т. 5. – С. 86. Ferrari S. L. et al. Diagnosis and management of bone fragility in diabetes: an emerging challenge //Osteoporosis International. – 2018. – Т. 29. – С. 2585-2596. Figeac F. et al. Impaired bone fracture healing in type 2 diabetes is caused by defective functions of skeletal progenitor cells //Stem Cells. – 2022. – Т. 40. – №. 2. – С. 149-164. Hamann C. et al. Delayed bone regeneration and low bone mass in a rat model of insulin- resistant type 2 diabetes mellitus is due to impaired osteoblast function //American Journal of Physiology-Endocrinology and Metabolism. – 2011. – Т. 301. – №. 6. – С. E1220- E1228. Hua Y. et al. Different bone sites-specific response to diabetes rat models: Bone density, histology and microarchitecture //PLoS One. – 2018. – Т. 13. – №. 10. – С. e0205503. Jackuliak P. et al. Osteoporosis, fractures, and diabetes //International journal of endocrinology. – 2014. – Т. 2014. Jiao H., Xiao E., Graves D. T. Diabetes and its effect on bone and fracture healing //Current osteoporosis reports. – 2015. – Т. 13. – С. 327-335. Khusainova Р. И. et al. МОЛЕКУЛЯРНО-ГЕНЕТИЧЕСКИЕ ОСНОВЫ ОСТЕОПОРОЗА GENETICS OF OSTEOPOROSIS //Биомика. – 2014. – Т. 6. – №. 1. – С. 24-51. Kum J. J. Y., Howlett C. J., Khan Z. A. Dysregulated transforming growth factor-beta mediates early bone marrow dysfunction in diabetes //Communications Biology. – 2022. – Т. 5. – №. 1. – С. 1145. Lin S. Impaired bone healing in patients with diabetes mellitus //The University of Medicine and Dentistry in New Jersey Research. – 2004. – Т. 5. – №. 4. Marin C. et al. The impact of type 2 diabetes on bone fracture healing //Frontiers in Endocrinology. – 2018. – Т. 9. – С. 6. Minami M. et al. Histological assessment of cortical bone changes in diabetic rats //Journal of Orthopaedic Surgery and Research. – 2022. – Т. 17. – №. 1. – С. 1-8. Murray C. E., Coleman C. M. Impact of diabetes mellitus on bone health //International Journal of Molecular Sciences. – 2019. – Т. 20. – №. 19. – С. 4873. Napoli N., Conte C. Bone fragility in type 1 diabetes: new insights and future steps //The Lancet Diabetes & Endocrinology. – 2022. – Т. 10. – №. 7. – С. 475-476. Neville R. F. et al. The diabetic foot //Current problems in surgery. – 2016. – Т. 53. – №. Oei L. et al. Diabetes, diabetic complications, and fracture risk //Current osteoporosis reports. – 2015. – Т. 13. – С. 106-115.